JaLCDOI 10.18926/AMO/31623
フルテキストURL fulltext.pdf
著者 Sugimoto, Yukio| Iba, Yoshionori| Ishizawa, Keisuke| Suzuki, Genzo| Kamei, Chiaki|
抄録 <p><p>The effects of levocabastine, a novel histamine H1-receptor antagonist, on lipid mediator release induced by antigen-antibody reaction from actively sensitized guinea pig lung fragments were studied. Levocabastine dose-dependently inhibited the release of leukotriene C4 from guinea pig lung fragments induced by antigen. A significant effect was observed with levocabastine at a concentration of 10(-4) M. On the other hand, levocabastine produced no effect on the release of leukotriene E4 or thromoboxane B2. From these findings, it was concluded that levocabastine may be useful for relieving the nasal obstruction in allergic rhinitis caused by inhibition of leukotriene C4 release.</p></p>
キーワード levocabastine guinea pig lung fragment lipid mediator
Amo Type Brief Note
発行日 1999-12
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 271
終了ページ 274
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 10631382
Web of Science KeyUT 000084414300005