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ID 31913
JaLCDOI
フルテキストURL
著者
Wakiguchi, Hiroshi Kochi Medical School
Fujieda, Mikiya Kochi Medical School
Matsumoto, Kenji Kochi Medical School
Ohara, Yuji Kochi Medical School
Wakiguchi, Akiko Kochi Medical School
Shiraishi, Taisuke Kochi Medical School
Kurashige, Takanobu Kochi Medical School
Kitamura, Isamu Kochi Medical School
抄録

Lymphocyte activation by streptolysin O (SLO) and factors in the plasma which inhibit the response to SLO were examined in 19 patients with mucocutaneous lymphnode syndrome (MCLS), 54 age-matched (6 months-6 years) normal children, 41 normal children older than 6 years and 10 normal adults. In normal children younger than 6 years, the response to SLO was weak and in many cases no response was seen. On the other hand, in the patients with MCLS, the response of lymphocytes to SLO was high and comparable to the response in adults and children older than 6 years. The DNA synthesis of lymphocytes stimulated by SLO was inhibited almost completely by autologous or allogeneic plasma of many of the normal children and adults. The plasma of patients with MCLS did not inhibit, but rather enhanced the response to SLO. These results suggest that the increased response of lymphocytes to SLO and the lack of plasma inhibitory factors in patients with MCLS may be due to the immune response to the pathogen of MCLS, as yet undiscovered.

キーワード
mucocutaneous lymphnode syndrome
streptolysin O
lymphocyte activation
plasma inhibitory factor (s)
Amo Type
Article
発行日
1986-12
出版物タイトル
Acta Medica Okayama
40巻
6号
出版者
Okayama University Medical School
開始ページ
285
終了ページ
289
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT