このエントリーをはてなブックマークに追加
ID 56202
フルテキストURL
著者
Takamura, Hiroyoshi Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
Katsube, Tomoya Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
Okamoto, Kazuki Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
Kadota, Isao Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
抄録
The first total synthesis of two possible diastereomers of natural 6-chlorotetrahydrofuran acetogenin 1 has been achieved. The synthetic route features 5-exo-tet cyclization, Z selective Wittig reaction and Julia olefination for the construction of conjugated diene and enyne moieties, and stereoselective chlorination. Comparison of their 1 H and 13 C NMR data and specific rotation with those of the natural product elucidated the absolute configuration of natural (-)-6-chlorotetrahydrofuran acetogenin 1.
キーワード
natural products
stereoselective synthesis
structure elucidation
tetrahydrofuran
total synthesis
備考
This is an article published by Wiley‐VCH
発行日
2017-12-06
出版物タイトル
Chemistry - A European Journal
23巻
68号
出版者
Wiley‐VCH
開始ページ
17191
終了ページ
17194
ISSN
09476539
NCID
AA11076269
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
著作権者
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン
author
PubMed ID
DOI
Web of Sience KeyUT
関連URL
isVersionOf https://doi.org/10.1002/chem.201703234