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ID 40735
フルテキストURL
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タイトル(別表記)
An experimental study of nitrogen metabolism in acute hepatic failure (Changes in guanidinoacetic acid level and kidney glycine amidinotransferase activity)
著者
株丹 浩二 岡山大学医学部麻酔・蘇生学教室
抄録
It was reported that serum guanidinoacetic acid (GAA) levels are elevated in acute hapatic failure. To explore the mechanism of this GAA level change, the activities of kidney glycine amidinotransferase (GAT) and liver GAA-methyltransferase (GAA-MT) were measured in experimental rat models of acute hepatic failure. GAA is synthesized by the former enzyme and catabolized by the latter enzyme. In the early stage, kidney GAT activity was increased (P<0.1) but the serum GAA level remained normal. In the late stage, liver GAA-MT activity was decreased (P<0.01) and serum GAA level was increased. From this result, it is concluded that GAA synthesis is increased in acute hepatic failure and that serum GAA level is increased when liver is severely damaged.
キーワード
急性肝不全
グアニジノ酢酸
グリシンアミヂノトランスフェラーゼ
発行日
1989-04
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
101巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
363
終了ページ
369
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/101/3-4/101_3-4_363/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma