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ID 32056
JaLCDOI
フルテキストURL
著者
Hatase, Osamu Okayama University
Fujii, Toshitake Okayama University
Kuramitsu, Makoto Okayama University
Itano, Toshifumi Okayama University
Takahashi, Fumio Okayama University
Murakami, Tetsuhide Okayama University
Nishida, Isamu Okayama University
抄録
Factors that inhibit and stimulate cell proliferation were found to coexist in rat liver supernatant. The inhibitory and stimulatory factors were separated by ethanol fractionation. Both factors were sensitive to heat- and trypsin-treatment. The activity of the inhibitor was diminished by partial hepatectomy. The inhibitor from normal livers inhibited DNA and RNA synthesis in the L-cell system, but the same fraction from regenerating livers caused little or no inhibition of nucleic acid synthesis. The stimulatory factor from regenerating livers had a stronger effect on cell proliferation than that of normal livers. Furthermore, the inhibitor from normal livers depressed DNA synthesis in vivo in regenerating livers.
キーワード
growth factors
growth stimulants
growth inhibitants
rat liver cytoplasm
cell proliferation
Amo Type
Article
発行日
1979-04
出版物タイトル
Acta Medica Okayama
33巻
2号
出版者
Okayama University Medical School
開始ページ
73
終了ページ
80
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID