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ID 48556
フルテキストURL
著者
Yoshimoto, Masaaki Graduate School of Health Sciences, Okayama University
Kataoka, Takahiro Graduate School of Health Sciences, Okayama University
Toyota, Teruaki Graduate School of Health Sciences, Okayama University
Taguchi, Takehito Graduate School of Health Sciences, Okayama University
Yamaoka, Kiyonori Graduate School of Health Sciences, Okayama University
抄録
We examined the inhibitory effects of low-dose X-irradiation on mouse brain tissue with cold-induced injury by comparing tissue samples from three groups of mice: control, sham-irradiated cold-exposed, and X-ray-irradiated (0.5 Gy) cold-exposed mice. The water content in brain increased significantly in the sham-irradiated group following the cold-induced injury relative to the control group. However, water content in brain tissue from the X-ray-irradiated group was significantly lower than that from the sham-irradiated group. Levels of antioxidants, such as superoxide dismutase and glutathione, in brain tissue from the X-ray-irradiated group were higher than those from the sham-irradiated group. Moreover, the cold injury-induced cell death, particularly apoptosis, while low-dose irradiation inhibited cell death, especially among glial cells, but not numeral cells. These findings suggest that prior low-dose X-irradiation activated antioxidant function and inhibited cold-induced brain injury.
キーワード
cold injury
brain edema
0.5 Gy irradiation
antioxidative function
発行日
2012-02-01
出版物タイトル
Inflammation
35巻
1号
出版者
Springer Science+Business Media, LLC
開始ページ
89
終了ページ
97
ISSN
0360-3997
資料タイプ
学術雑誌論文
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/48543
言語
English
OAI-PMH Set
岡山大学
著作権者
© Springer Science+Business Media, LLC 2011
論文のバージョン
author
査読
不明
DOI
PubMed ID
Web of Sience KeyUT