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ID 48710
フルテキストURL
著者
Kataoka, Takahiro Graduate School of Health Sciences, Okayama University
Mizuguchi, Yuko Graduate School of Health Sciences, Okayama University
Yoshimoto, Masaaki Graduate School of Health Sciences, Okayama University
Taguchi, Takehito Graduate School of Health Sciences, Okayama University
Yamaoka, Kiyonori Graduate School of Health Sciences, Okayama University
抄録
We have reported that low-dose, unlike high-dose, irradiation enhanced antioxidation function and reduced oxidative damage. On the other hand, ischemia-reperfusion injury is induced by reactive oxygen species. In this study, we examined the inhibitory effects of prior low-dose X-irradiation on ischemia-reperfusion injury in mouse paw. BALB/c mice were irradiated by sham or 0.5 Gy of X-ray. At 4 hrs after irradiation, the left hind leg was bound 10 times with a rubber ring for 0.5, 1, or 2 hrs and the paw thickness was measured. Results show that the paw swelling thickness by ischemia for 0.5 hr was lower than that for 2 hrs. At 1 hr after reperfusion from ischemia for 1 hr, superoxide dismutase activity in serum was increased in those mice which received 0.5 Gy irradiation and in the case of the ischemia for 0.5 or 1 hr, the paw swelling thicknesses were inhibited by 0.5 Gy irradiation. In addition, interstitial edema in those mice which received 0.5 Gy irradiation was less than that in the mice which underwent by sham irradiation. These findings suggest that the ischemia-reperfusion injury is inhibited by the enhancement of antioxidation function by 0.5 Gy irradiation.
キーワード
Edema
Ischemia-reperfusion injury
Low-dose irradiation
Reactive oxygen species
Antioxidation function
発行日
2007-11-21
出版物タイトル
Journal of Radiation Research
48巻
6号
出版者
Journal of Radiation Research Editorial Committee
開始ページ
505
終了ページ
513
ISSN
0449-3060
NCID
AA00705792
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/jrr/48/6/48_6_505/_article
言語
English
著作権者
Copyright © 2007 by Journal of Radiation Research Editorial Committee
論文のバージョン
publisher
査読
有り
DOI
PubMed ID
Web of Sience KeyUT