このエントリーをはてなブックマークに追加
ID 48713
フルテキストURL
著者
Kataoka, Takahiro Graduate School of Health Sciences, Okayama University
Yoshimoto, Masaaki Graduate School of Health Sciences, Okayama University
Nakagawa, Shinya Graduate School of Health Sciences, Okayama University
Mizuguchi, Yuko Radiation Safety Research Center, Central Research Institute of Electric Power Industry
Taguchi, Takehito Graduate School of Health Sciences, Okayama University
Yamaoka, Kiyonori Graduate School of Health Sciences, Okayama University
抄録
We previously reported that low-dose X-irradiation alleviates ischemia-reperfusion injury such as mouse paw edema. In this study, we examined active changes in the biological function of mouse liver grafts in cold storage after low-dose X-irradiation. Mouse livers were sham-irradiated or were irradiated with 0.25, 0.5, 1.0, or 5.0 Gy of X-ray and stored for 4, 8, 24, or 48 h in preservation or saline solution. The results show that storage for 24 h in saline solution after 0.5 Gy irradiation significantly increased the activity of superoxide dismutase (SOD) and catalase. Following storage for 4, 8, or 48 h in preservation solution, lipid peroxide levels of the 0.5 Gy irradiated group were significantly lower than those of the sham irradiated group. Following storage for 24 h in preservation solution, the activity of SOD and catalase of the 1.0 Gy irradiated group were significantly higher than those of the sham irradiated group. Hepatocytes stored in saline solution were vacuolated. However, no vacuole formation was observed in hepatocytes stored in preservation solution. These findings suggest that low-dose irradiation significantly activates antioxidative functions of liver grafts. Moreover, the dose at which enhancement of antioxidative function occurs in livers stored in preservation solution, which contains glutathione, is significantly higher than that in saline solution.
キーワード
organ transplantation
low-dose irradiation
antioxidative function
hepatopathy
発行日
2009-09
出版物タイトル
Journal of Clinical Biochemistry and Nutrition
45巻
2号
出版者
The Editorial Secretariat of JCBN
開始ページ
219
終了ページ
226
ISSN
0912-0009
NCID
AA10710201
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/jcbn/45/2/45_09-06/_article
言語
English
OAI-PMH Set
岡山大学
著作権者
Copyright © 2009 by The Editorial Secretariat of JCBN
論文のバージョン
publisher
査読
有り
DOI
Web of Sience KeyUT