このエントリーをはてなブックマークに追加
ID 48719
フルテキストURL
著者
Nishiyama, Yuichi Graduate School of Health Sciences, Okayama University
Kataoka, Takahiro Graduate School of Health Sciences, Okayama University
Teraoka, Junichi Graduate School of Health Sciences, Okayama University
Sakoda, Akihiro Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Ishimori, Yuu Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
Yamaoka, Kiyonori Graduate School of Health Sciences, Okayama University
抄録
Radon inhalation activates antioxidative functions in some organs of mice. We examined the prevention effects of pre radon inhalation and the alleviation effects of post radon inhalation on carbon tetrachloride (CCl4)-induced oxidative damage in the brain, heart, lung, liver, and kidney of mice. In addition, we compared the effect of pre and post radon inhalation on oxidative damage. Mice inhaled radon at a concentration of 18000Bq/m3 for 6hrs before or after CCl4 administration. As a result, the total glutathione(t-GSH) contents and catalase(CAT) activities in the brain, heart, lung, liver, and kidney and superoxide dismutase(SOD) activities in the heart and lung were significantly higher in pre and post radon-inhaled mice than in mice treated with only CCl4. Pre radon inhalation inhibited and post radon inhalation reduced lipid peroxidation induced by CCl4. In addition, there were no significant differences in lipid peroxide(LPO) levels in the brain, heart, lung, liver, and kidney between pre and post radon-inhaled mice. These findings suggested that post radon inhalation has the same effects as pre radon inhalation against CCl4-induced oxidative damage in the brain, heart, lung, liver, and kidney.
キーワード
carbon tetrachloride
oxidative damage
pre or post radon inhalation
antioxidative function
発行日
2012-05-29
出版物タイトル
RADIOISOTOPES
61巻
5号
出版者
Japan Radioisotope Association
開始ページ
231
終了ページ
241
ISSN
0033-8303
NCID
AN00351589
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/radioisotopes/61/5/61_231/_article/
言語
English
著作権者
Copyright © 2012 by Japan Radioisotope Association
論文のバージョン
publisher
査読
有り
DOI