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ID 52015
フルテキストURL
著者
Toyota, Teruaki Okayama Univ, Grad Sch Hlth Sci
Kataoka, Takahiro Okayama Univ, Grad Sch Hlth Sci
Nishiyama, Yuichi Okayama Univ, Grad Sch Hlth Sci
Taguchi, Takehito Okayama Univ, Grad Sch Hlth Sci
Yamaoka, Kiyonori Okayama Univ, Grad Sch Hlth Sci
抄録
We previously reported that radon inhalation activates antioxidative functions in the liver and inhibits carbon tetrachloride-induced hepatopathy in mice. In addition, it has been reported that reactive oxygen species contribute to alcohol-induced hepatopathy. In this study, we examined the inhibitory effects of radon inhalation on acute alcohol- induced hepatopathy in mice. C57BL/6J mice were subjected to intraperitoneal injection of 50% alcohol (5 g/kg bodyweight) after inhaling approximately 4000 Bq/m(3) radon for 24 h. Alcohol administration significantly increased the activities of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) in serum, and the levels of triglyceride and lipid peroxide in the liver, suggesting acute alcohol- induced hepatopathy. Radon inhalation activated antioxidative functions in the liver. Furthermore, pretreatment with radon inhibited the depression of hepatic functions and antioxidative functions. These findings suggested that radon inhalation activated antioxidative functions in the liver and inhibited acute alcohol- induced hepatopathy in mice.
発行日
2012
出版物タイトル
Mediators of Inflammation
2012巻
ISSN
0962-9351
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/10.1155/2012/382801
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/51997
言語
English
OAI-PMH Set
岡山大学
著作権者
© 2012 Teruaki Toyota et al.
論文のバージョン
publisher
査読
有り
DOI