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ID 17690
Eprint ID
17690
フルテキストURL
Thumnail 88_1055.pdf 2.76 MB
タイトル(別表記)
Neocarzinostatin effect on immune response of mice 1. Effects on humoral immunity
著者
三河内 弘 岡山大学医学部第二内科教室
抄録
Since tumor-antitumor agent-host correlation must be considered in the treatment of neoplasms, the qualitative change of serum protein and hemolytic plaque forming cell (HPFC) production against sheep red blood cells (SRBC) in mice were carefully studied in part 1 to investigate the effect of a new antileukemic agent, Neocarzinostatin (NCS), on humoral immunity. Serum gamma globulin significantly decreased by the 4(th) day and returned to normal by the 12th day after a single injection of NCS. After 4 consecutive days of NCS administration gamma globulin value showed no change, but after 7 consecutive days of NCS 0.50mg/kg/day administration marked gamma globulin reduction was observed. Marked reduction of HPFC was observed in the -8(th) and -4(th) day groups of the single injection of NCS, but the -12(th), O, +2(nd) and +4(th) day groups showed only moderate reduction (Immunization by SRBC was done on 0 day.). After 4 consecutive days of NCS injection only 0.50mg/kg/day group showed HPFC reduction. But after 7 consecutive days of NCS administration 0.005mg/kg/day group showed moderate and 0.05mg/kg/day group showed marked reduction of HPFC. All mice in 0.50mg/kg/day group died. These data suggest that NCS suppresses the humoral immunity of mice to some extent and it affects almost all phases of the immune response but mainly the afferent phase. Furthermore, immunosuppressive effects of NCS are related to the daily dose and the number of consecutive days of NCS administration.
発行日
1976-12-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
88巻
11-12号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1055
終了ページ
1066
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/88/11-12/88_11-12_1055/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma