JaLCDOI 10.18926/AMO/31107
フルテキストURL fulltext.pdf
著者 Maekawa, Kiyoaki| Saito, Daiji| Kobayashi, Hiroo| Mizuo, Kouzo| Obayashi, Naotsugu| Uchida, Shinji| Haraoka, Shoichi|
抄録 <p>Nipradilol is a newly synthesized beta-blocker which has a propranolol-like structure and contains a nitrate moiety. To examine the effect of nipradilol on venous blood flow, a single oral dose of nipradilol (6 mg) and propranolol (20 mg) was administered in the same 15 normal volunteers on separate days. Peak flow velocities, flow velocity integrals, and the diameter of the right brachiocephalic vein were measured before and 2 h after drug administration using Doppler echocardiography. These two beta-blockers significantly decreased systolic blood pressure to the same extent as they did heart rate. Nipradilol dilated the venous diameter by 8% and decreased peak flow velocity by 8% during systole and 9% during diastole. The flow velocity integral in one cardiac cycle also decreased significantly by 14%. Propranolol, however, failed to modify these parameters. These results suggest that nipradilol decreased venous return through its nitroglycerin-like direct vasodilating action.</p>
キーワード Doppler echocardiography venous return nipradilol
Amo Type Article
発行日 1994-04
出版物タイトル Acta Medica Okayama
48巻
2号
出版者 Okayama University Medical School
開始ページ 87
終了ページ 91
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 8042538
Web of Sience KeyUT A1994NJ77500004