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ID 31107
JaLCDOI
フルテキストURL
著者
Maekawa, Kiyoaki Okayama University
Saito, Daiji Okayama University
Kobayashi, Hiroo Okayama Univeristy
Mizuo, Kouzo Okayama University
Obayashi, Naotsugu Okayama University
Uchida, Shinji Okayama University
Haraoka, Shoichi Okayama University
抄録

Nipradilol is a newly synthesized beta-blocker which has a propranolol-like structure and contains a nitrate moiety. To examine the effect of nipradilol on venous blood flow, a single oral dose of nipradilol (6 mg) and propranolol (20 mg) was administered in the same 15 normal volunteers on separate days. Peak flow velocities, flow velocity integrals, and the diameter of the right brachiocephalic vein were measured before and 2 h after drug administration using Doppler echocardiography. These two beta-blockers significantly decreased systolic blood pressure to the same extent as they did heart rate. Nipradilol dilated the venous diameter by 8% and decreased peak flow velocity by 8% during systole and 9% during diastole. The flow velocity integral in one cardiac cycle also decreased significantly by 14%. Propranolol, however, failed to modify these parameters. These results suggest that nipradilol decreased venous return through its nitroglycerin-like direct vasodilating action.

キーワード
Doppler echocardiography
venous return
nipradilol
Amo Type
Article
発行日
1994-04
出版物タイトル
Acta Medica Okayama
48巻
2号
出版者
Okayama University Medical School
開始ページ
87
終了ページ
91
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT