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ID 16278
Eprint ID
16278
フルテキストURL
Thumnail 95_263.pdf 431 KB
タイトル(別表記)
Studies on peripheral monocytes in diabetes mellitus. Part II. Lysosomal enzyme activity of monocyte in diabetes mellitus.
著者
宮原 潔 岡山大学医学部第2内科教室
抄録
Lysosomal enzyme activities of diabetic monocytes were studied using cytochemical staining of beta-galactosidase and non-specific esterase. The enzyme activity of each monocyte was graded from (-) to (++++) depending on the staining strength. The results were as follows: 1) The beta-galactosidase(β-GAL) activity of monocytes from 23 normal controls was 40.3±20.2% and that of 49 diabetics was 42.6±20.1% , with no difference between diabetics and normal controls in graded β-GAL activity. 2) The degree of diabetic control and the way of therapy did not affect the β-GAL activities. 3) Non-specific esterase(NSE) activities of 37 normal controls and 41 diabetics were 94.0±6.3% and 95.9±6.9% , respectively. The enzyme activities of each grade were different between the two groups, that is, (+++) NSE activity was significantly lower in diabetics than in normal controls (28.7±14.1% vs 47.4±17.9% , P<0.001). On the contrary, (+) and (++) NSE activities of diabetics were significantly higher than those of normal controls. 4) There was no difference in NSE activities depending on the way of therapy. Poorly controlled diabetics had significantly lower (+++) and (++++) NSE activities than others. 5) Further evaluation of NSE activity using the scoring method by Kaplow revealed no difference between diabetics and normal controls. 6) The total monocyte NSE activity, which was calculated from the NSE score multiplied by the absolute monocyte count was lower in diabetics than in normal controls, although there was no difference in the absolute peripheral monocyte count between the two groups.
キーワード
糖尿病 (diabetes mellitus)
単球 (monocyte)
ライソゾーム酵素 (lysosomal enzyme)
発行日
1983-04-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
95巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
263
終了ページ
270
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/95/3-4/95_3-4_263/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma