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ID 13528
Eprint ID
13528
フルテキストURL
Thumnail 115_15.pdf 3.21 MB
タイトル(別表記)
Relationship between formation of HCV-bearing immune complexes and response to inteferon therapy for chroic hepatitis C
著者
眞鍋 良二 Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry
抄録
We retrospectively analyzed the relationship between formation of HCV-bearing immune complexes (HCV-IC) and response to interferon (IFN) therapy for chronic hepatitis C (CH-C). Five CH-C patients with complete response (CR) to IFN therapy and pre-treatment HCV RNA titer measured by Amplicor HCV-monitor and five stage (biopsy proved fibrosis of the liver)-matiched CH-C patients who were non-esponders (NR) to IFN therapy were enrolled. Pretretment sera were separated into HCV-IC (supernatant) and anti-HCV antibody-free virions (pellet) by addition of anti-human immunoglobulins and centrifugation. HCV RNA was quantified in the supernatant and the pellet, by real-time PCR and semi-quantitative RT-PCR respectively. There were discrepancies in the HCV RNA titers measured by Amplicor and the results of real-time PCR. We found a larges quantity of HCV RNA in the supernatan and a smaller quantity in the pellet in CR than in NR by using by real-time PCR. Our data indicate that response to interferon therapy for CH-C patients may be associated with the conditions underlying the formation of HCV-IC.
キーワード
HCV
chronic hepatitisC
HCV-immune complexes
備考
原著
発行日
2005-05-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
115巻
1号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
15
終了ページ
19
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/115/1/115_1_15/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
Copyright© 岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma