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ID 13830
Eprint ID
13830
フルテキストURL
Thumnail 105_673.pdf 420 KB
タイトル(別表記)
Experimental studies on nicaraven as a radioprotector : Survival ratio of mice, spleen colony formation, blood picture and lipid peroxidation
著者
森 泰胤 香川医科大学放射線医学教室
高島 均 香川医科大学放射線医学教室
瀬尾 裕之 香川医科大学放射線医学教室
大川 元臣 香川医科大学放射線医学教室
田邉 正忠 香川医科大学放射線医学教室
山本 剛禧 岡山大学医療技術短期大学部診療放射線技術学科
抄録
The degree of radiation protection from Nicaraven after whole-body irradiation was investigated in C3H mice. Nicaraven is a free radical scavenging agent, which was shown to improve brain edema and blood flow. Nicaraven was injected intraperitoneally in mice before and/or after whole-body irradiation with 640cGy or 740cGy using Toshiba Lineac LMR-4C (4MV, 6.45×10(-2)C/㎏/min). The 30 day survival ratio was improved significantly by Nicaraven (P≦0.02). Endogenous spleen colony formation was investigated after 640cGy. The agent was injected before (pre), after (post) or before and after irradiation (pre-post), and compared with the untreated group (control). Nine days after irradiation, the mean colony formation was 2.00 (pre), 3.09 (post), 4.31 (pre-post) and 1.47 (control). The differences between pre and post (p≦0.01), between pre-post and control (p≦0.01) and between post and control (p≦0.05) were significant. Nicaraven induced recovery of leukocyte and lymphocyte counts after irradiation, but not that of erythrocytes. The effect of the agent on mice liver mitochondrial lipid peroxidation was also investigated. The lag time was not shortened, but reduction of the TBA value was observed. Nicaraven was not only recognized as a radioprotector, but its ability to promote recovery from the damage caused by irradiation was also suggested.
キーワード
Radioprotector
Nicaraven
Radical scavenger
Spleen colony
Lipid peroxidation
備考
原著
発行日
1993-08
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
105巻
7-8号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
673
終了ページ
680
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/105/7-8/105_7-8_673/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma