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ID 31728
JaLCDOI
フルテキストURL
著者
Nomoto, Hiroyuki Okayama University
Oohashi, Toshitaka Okayama University
Hirakawa, Satoshi Okayama University
Ueki, Yasuyoshi Okayama University
Ohtsuki, Hiroshi Okayama University
Ninomiya, Yoshifumi Okayama University
抄録

We herein determined by fluorescence in situ hybridization the chromosomal localization of 2 human genes, BRAL1 and BCAN, both of which belong to the link-module superfamily, i.e. to the same band of chromosome 1q21-23. Further analysis of the genomic organization of BRAL1 and BCAN revealed that the BRAL1 gene was located 20-kb upstream of the BCAN start site. We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the BCAN gene. High heterozygosity (0.79) makes this polymorphism a useful marker in the study of genetic disorders. Knowledge of the structure of the genes and the marker provides essential information for further analysis of the gene locus at chromosome 1q21-23.

キーワード
BRAL1
BCAN
FISH
schizophrenia
polymorphic marker
Amo Type
Article
発行日
2002-02
出版物タイトル
Acta Medica Okayama
56巻
1号
出版者
Okayama University Medical School
開始ページ
25
終了ページ
29
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT