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ID 11822
Eprint ID
11822
フルテキストURL
タイトル(別表記)
Sarcoidosis and Propionibacterium acnes
著者
中田 安成 岡山大学医療技術短期大学部衛生技術学科
片岡 幹男 岡山大学医学部第2内科
木村 郁郎 岡山大学医学部第2内科
抄録
Although there have been numerous reports on the isolation of bacteria, fungus, and aetiological agents of chemical substances from specimens of patients with sarcoidosis, none of them have been substantiated. In any event, an understanding of the pathogenesis of pulmonary sarcoid is intimately linked to that of the processes involved in the accumulation of T-cells in the lower respiratory tract of individuals with sarcoidosis. Propionibacterium acnes was isolated at high rates and in high concetrations from lymph nodes in patients with sarcoidosis. However, the precise mechanism of granuloma formation and immunomodulation by P. acnes has not been elucidated yet. In patients with sarcoidosis, it was found that the high levels of interleukin-2 (IL-2) released from alveolar lymphocytes as well as interleukin-1, tumor necrosis factor (TNF) and interleukin-6 (IL-6) released from alveolar macrophages were stimulated by P. acnes. These cytokines (mainly IL-2), released by P. acnes in large quantities, play a major role in the compartmentalization of the T-cell population in the lung and lead to the formation of an alveolitis and granuloma in the lung parenchyma of patients with sarcoidosis. This paper focuses primarily on the role of the cytokine network in the pulmonary mononuclear cells in the lung of patients with sarcoidosis.
キーワード
sarcoidosis
macrophage
T-cell
interleukin-2
Propionibacterium acnes
発行日
1993-01-31
出版物タイトル
岡山大学医療技術短期大学部紀要
出版物タイトル(別表記)
Bulletin of School of Health Sciences Okayama University
3巻
出版者
岡山大学医療技術短期大学部
出版者(別表記)
School of Health Sciences Okayama University
開始ページ
19
終了ページ
36
ISSN
0917-4494
NCID
AN10355371
資料タイプ
紀要論文
言語
Japanese
論文のバージョン
publisher
査読
無し
Eprints Journal Name
fhs