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ID 14393
Eprint ID
14393
フルテキストURL
Thumnail 104_355.pdf 1.32 MB
タイトル(別表記)
Superoxide dismutase activity in rheumatoid arthritis : its measurement and clinical implication
著者
尾上 仁一 岡山大学医学部整形外科学教室
抄録
In chronic inflammations of rheumatoid arthritis (RA), polynuclear leukocytes, macro-phages, synovial cells and other inflammatory cells release reactive oxygen species (ROS) and cause tissue impairment, and are regarded as the responsible agents in this pathological condition. In the present study, the electron spin resonance (ESR) method was used to measure superoxide dismutase (SOD) in 76 knee synovial fluid samples from rheumatoid knee joints and to compare the results with those of osteoarthritic knee joints and postraumatic arthritis. There was no significant difference in the SOD activity between PA and OA patients knee joint fluid, which was higher than that in patients with posttraumatic arthritis. The SOD activity in RA knee joint fluid showed no correlation with serum CRP (C-reactive protein) or erythrocyte sedimentation rate, indices of inflammation. According to Larsen's Grading of rtheumatoid knee radiography, patients with moderate RA changes (grade Ⅲ or Ⅳ) show higher SOD activity than patients with early (grade Ⅰ or Ⅱ) and terminal RA (grade Ⅴ). Our findings suggest that the SOD actvity in RA knee joint fluid is a valid index of articular destruction.
キーワード
superoxide dismutase
rheumatoid arthritis
electron spin resonance
発行日
1992
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
104巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
355
終了ページ
364
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/104/3-4/104_3-4_355/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma