このエントリーをはてなブックマークに追加
ID 14393
Eprint ID
14393
フルテキストURL
Thumnail 104_355.pdf 1.32 MB
タイトル(別表記)
Superoxide dismutase activity in rheumatoid arthritis : its measurement and clinical implication
著者
尾上 仁一 岡山大学医学部整形外科学教室
抄録
In chronic inflammations of rheumatoid arthritis (RA), polynuclear leukocytes, macro-phages, synovial cells and other inflammatory cells release reactive oxygen species (ROS) and cause tissue impairment, and are regarded as the responsible agents in this pathological condition. In the present study, the electron spin resonance (ESR) method was used to measure superoxide dismutase (SOD) in 76 knee synovial fluid samples from rheumatoid knee joints and to compare the results with those of osteoarthritic knee joints and postraumatic arthritis. There was no significant difference in the SOD activity between PA and OA patients knee joint fluid, which was higher than that in patients with posttraumatic arthritis. The SOD activity in RA knee joint fluid showed no correlation with serum CRP (C-reactive protein) or erythrocyte sedimentation rate, indices of inflammation. According to Larsen's Grading of rtheumatoid knee radiography, patients with moderate RA changes (grade Ⅲ or Ⅳ) show higher SOD activity than patients with early (grade Ⅰ or Ⅱ) and terminal RA (grade Ⅴ). Our findings suggest that the SOD actvity in RA knee joint fluid is a valid index of articular destruction.
キーワード
superoxide dismutase
rheumatoid arthritis
electron spin resonance
発行日
1992
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
104巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
355
終了ページ
364
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/104/3-4/104_3-4_355/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
参考文献
1) Igari T, Kaneda H, Horiuchi S and Ono S : A remarkable increase of superoxide dismutase activity in synovial fluid of patients with rheumatoid arthritis. Clin Orthop Relat Res (1982) 162, 282-287.
2) 鎌田俊之 : 慢性関節リウマチ患者における Superoxide Dismutase および高気圧酸素療法に関する研究. 日整外会誌 (1985) 59, 17-26.
3) Chapman ML, Bernard R and Robert WG : Increased carbonyl content of proteins in synovial fluid from patients with rheumatoid artritis. J Rheumatol (1989) 16, 15-18.
4) Marklund SL, Bjelle A and Elmqvist LG : Superoxide dismutase isoenzymes of the synovial fluid in rheumatoid arthritis and reactive artritides. Ann Rheum Dis (1986) 45, 847-851.
5) 丹波靭負 : 炎症と活性酸素. リウマチ (1983) 23, 237-253.
6) Janzen EG : Spin trapping. Accounts Chem Res (1971) 4, 31-40.
7) Harbour JR, Chow V and Bolton JR : An electron spin resonance study of the spin adducts of OH and HO2 radicals with nitrons in the ultraviolet photolysis of aqueous hydrogen peroxide solutions. Can J Chem (1974) 52, 3549-3553.
8) Janzen EG, Nutter DE and Davis ED : On spin trapping hydroxyl and hydroperoxyl radicals. Can J Chem (1978) 56, 2237-2242.
9) Hiramatsu M, Kohno M, Edamatsu R, Mitsuta K and Mori A : Increased superoxide dismutase activity in aged human cerebrospinal fluid and rat brain determined by electron spin resonance spectrometry using the spin trap method. J Neurochem (1992) in press.
10) Hilton JG, Brown GL and Proctor PH : Effect of superoxide dismutase and catelase on central nervous system toxicity of hyperbaric oxygen. Toxicol Appl Pharmacol (1980) 53, 50-53.
11) Hiramatsu M and Kohno M : Determination of superoxide dismutase activity by electron spin resonance spectrometry using the spin trap method. JEOL News (1987) 23, 7-9.
12) Hiramatsu M, Edamatsu R, Sato K, Koide N, Kohno M and Mori A : Superoxide dismutase activity in cerebrospinal fluid of patients ; in Medical Biochemical and Chemical Aspects of Free Radicals. Hayashi O ed, Elsevier, Amsterdam (1989) pp.869-872.
13) Arnett FC, Edworthy SM and Bloch DA : The american rheumatism association 1987 revised crieria for the classification of rheumatoid arthritis. Arthritis Rheum (1988) 31, 315.
14) Steinbrocker O, Traeger CH and Batterman RC : Therapeutic criteria in rheumatoid arthritis. J Am Med Assoc (1949) 140, 659-662.
15) 腰野富久 : 膝疾患治療成績判定基準委員会. RA 膝治療成績判定基準. 日整外会誌 (1988) 62, 900-903.
16) Larsen A : Radiological grading of rheumatoid arthritis. An interobserver study. Scand J Rheumatol (1973) 2, 136-138.
17) Larsen A : The value of individual joints for radiologic assessment of rheumatoid arthritis. Scand J Rheumatol (1976) 5, 119-123.
18) Leena P, Jaakko P, Martti H and Kalevi K : Histopathological findings in joint diseases. Scand J Rheumatol (1981) 10, 115-123.
19) 丹波靭負, 石本浩市, 坂根 剛, 神宮政男 : Rheumatoid arthitis (RA) 患者関節液の stimulated-neutrophilis のもたらすリンパ球および組織に対する auto-oxidative damage について. 日内会誌 (1982) 71, 24-36.
20) Takasugi S and Inouse H : Histopathology of the cartilage-bone junction in rhematoid arthritis. Acta Med Okayama (1988) 42, 83-85.
21) 末長 敢 : 慢性関節リウマチ膝関節における骨・軟骨移行部の病態に関する研究. 岡山医誌 (1988) 100, 959-970.
22) Jasin HE and Dingle JT : Human mononuclear cell factors mediate cartiage matrix degradation through chondrocyte activation. J Clin Invest (1981) 68, 571-581.
23) Dayer JM, Breard J and Chess L : Participation of monocyte-macrophages and lymphocytes in the synovial cells. J Clin Invest (1979) 64, 1386-1392.
24) 金田博史 : 慢性関節リウマチ患者における過酸化脂質とその消去酵素に関する研究. 日整外会誌 (1982) 56, 387-397.
25) Fridovich I and Mccord JM : Superoxide dismutase. J Biol Chem (1969) 244, 6049-6055.
26) Imadaya A, Terasawa K, Tosa H, Okamoto M and Torzuka K : Erythrocyte anti-oxidant enzymes are reduced in patients with rheumatoid arthritis. J Rheumatol (1988) 15, 1628-1631.
27) 住居広士, 井上 一, 尾上仁一, 横山良樹, 森 昭胤 : 変形型膝関節症における SOD の測定と臨床的意義について. 中部整災誌 (1992)(投稿中).
28) Hollingsworth JW : Granulocyte surivial in synovial exdate of patient with rheumatoid arthritis and other inflammatory. Yale J Biol Med (1967) 39, 289-296.
29) Soren A : Histodiagnosis and clincal correlation of rheumatoid and other synovitis. Lippinocott Philadelphia (1978) pp.148-161.
30) Muirden KD : Giant cells, cartilage and bone fragments witin rheumatoid synovial membrane. clinico-pathological correlations. Aust Ann Med (1970) 2, 105-110.
31) Klaus M, Goebel MDU and Storck MD : Effect of intra-articular orgotein versus a corticosteroid on rheumatoid arthritis of the knees. Am J Med (1983) 7, 124-128.
32) 山岡聖典, 松枝 礼, 森 昭胤 : 低線量照射による生体機能活性. 電力中央研究所報告 (1990) 1-25.
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma