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ID 40686
フルテキストURL
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タイトル(別表記)
Studies on intractable factors in bronchial asthma Part 1. Mechanisms of the late asthmatic response in an animal model
著者
沖 和彦 岡山大学医学部第二内科学教室
抄録
In order to investigate in detail the mechanism of late asthmatic responses (LAR) which seem to be involved in the development of intractable asthma, we prepared an experimental model of bronchial asthma using guinea pigs and examined neutrophil, eosinophil, and leukotriene (LTs) levels in venous blood and bronchoalveolar lavage fluid (BALF). Our results suggest that leukocytosis, and especially neutrophilia and eosinophilia is found in venous blood more with LAR than in IAR and non-attack states in control animals (P<0.01). Moreover, increased neutrophils were found in BALF in LAR compared with IAR and controls (P<0.01) and marked eosinophil infiltration was observed in the peribronchial tissue in LAR compared with IAR and control (P<0.01). Finally LTC4 levels were high in the venous blood and BALF in IAR, and LTB4 levels were also high in BALF in LAR. The data suggests that the accumulation of neutrtophils and eosinophils in peribronchial areas and release of leukotrienes in BALF play important roles in the etiology of LAR.
キーワード
Actively sensitized model
Guinea pig
Late asthmatic response
BAL-cell
Leukotrienes
発行日
1990-10
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
102巻
9-10号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1187
終了ページ
1196
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/102/9-10/102_9-10_1187/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
OAI-PMH Set
岡山大学
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Sort Key
16
Eprints Journal Name
joma