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ID 40687
フルテキストURL
タイトル(別表記)
Studies on intractable factors in bronchial asthma Part 2. Effect of re-inhalation of antigen in the late asthmatic response in an animal model
著者
沖 和彦 岡山大学医学部第二内科学教室
抄録
In investigating the etiological mechanisms of intractable asthma, ascaris suum was used as a sensitizing antigen in experimental animal models of re-inhalation in the late asthmatic response (LAR). Our results suggest that marked expiratory prolongation was caused by re-inhalation of the antigen in LAR. Moreover, the number of neutrophils and eosinophils increased in BALF after re-inhalation of the antigen more in LAR than in IAR (P<0.01). Finally the level of LTC4 and LTB4 increased in the venous blood and BABF after reinhalation during the LAR. The data suggests that cellular reactions among neutrophils, eosinophils, and other cells migrating into the airway lumen are seen in LAR, and moreover, LTC4 and LTB4 may be important chemical mediators in prolonged asthmatic attacks.
キーワード
Actively sensitized model
Late asthmatic response
Re-inhalation
BAL-cell
Leukotrienes
発行日
1990-10
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
102巻
9-10号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1197
終了ページ
1205
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/102/9-10/102_9-10_1197/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
OAI-PMH Set
岡山大学
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Sort Key
17
Eprints Journal Name
joma