著者 Nagase, Ryo| Kajitani, Nobuo| Shikata, Kenichi| Ogawa, Daisuke| Kodera, Ryo| Okada, Shinichi| Kido, Yuichi| Makino, Hirofumi|
発行日 2012-10
出版物タイトル Clinical and Experimental Nephrology
16巻
5号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/45266
フルテキストURL 65_2_81.pdf
著者 Sasaki, Motofumi| Shikata, Kenichi| Okada, Shinichi| Miyamoto, Satoshi| Nishishita, Shingo| Usui Kataoka, Hitomi| Sato, Chikage| Wada, Jun| Ogawa, Daisuke| Makino, Hirofumi|
抄録 Glomerular hyperfiltration is a common pathway leading to glomerulosclerosis in various kinds of kidney diseases. The 5/6 renal ablation is an established experimental animal model for glomerular hyperfiltration. On the other hand, low-grade inflammation is also a common mechanism for the progression of kidney diseases including diabetic nephropathy and atherosclerosis. Here we analyzed the gene expression profile in the remnant kidney tissues of 5/6 nephrectomized mice using a DNA microarray system and compared it with that of sham-operated control mice. The 5/6 nephrectomized mice showed glomerular hypertrophy and an increase in the extracellular matrix in the glomeruli. DNA microarray analysis indicated the up-regulated expression of various kinds of genes related to the inflammatory process in remnant kidneys. We confirmed the up-regulated expression of platelet factor-4, and monocyte chemoattractant protein-1, 2, and 5 in remnant kidneys by RT-PCR. The current results suggest that the inflammatory process is involved in the progression of glomerulosclerosis and is a common pathway of the pathogenesis of kidney disease.
キーワード kidney inflammation chemokine
Amo Type Original Article
発行日 2011-04
出版物タイトル Acta Medica Okayama
65巻
2号
出版者 Okayama University Medical School
開始ページ 81
終了ページ 89
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 21519365
Web of Science KeyUT 000289818800003
JaLCDOI 10.18926/AMO/32128
フルテキストURL fulltext.pdf
著者 Okada, Shinichi|
Amo Type Article
発行日 1930-03
出版物タイトル Arbeiten aus der Medizinischen Universität zu Okayama
1巻
4号
開始ページ 503
終了ページ 514
NCID AA00508452
資料タイプ 学術雑誌論文
言語 German
論文のバージョン publisher
査読 有り
NAID 120002312075