JaLCDOI 10.18926/AMO/31136
フルテキストURL fulltext.pdf
著者 Okamoto, Yasuhisa| Tanaka, Noriaki| Orita, Kunzo|
抄録 <p>We investigated the effects of lymphokine-activated killer (LAK) cells on epidermal hyperplasia induced by cholera toxin (CT). LAK cells showed cytotoxic activity against both tumor cell lines and proliferating normal cells including skin epidermal cells. When 1 x 10(7) LAK cells were injected intradermally together with 1.0 ng of CT, epidermal hyperplasia was markedly suppressed. The LAK effectors inhibiting epidermal hyperplasia showed surface phenotypes of asialo-GM1+, Thy-1+, Lyt-2- and L3T4-, that were different from those of LAK cells killing tumor cells in vitro. Epidermal hyperplasia induced by CT was not suppressed by topical administration of cytokines such as interleukin-2, interferon and tumor necrosis factor. Therefore, the antiproliferative effect of LAK cells might be attributed to their direct action on the epidermal cells.</p>
キーワード lymphokine-activated killer cell cholera toxin epidermal proliferation cytokine
Amo Type Article
発行日 1994-02
出版物タイトル Acta Medica Okayama
48巻
1号
出版者 Okayama University Medical School
開始ページ 17
終了ページ 23
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 8191912
Web of Science KeyUT A1994MY85100003
JaLCDOI 10.18926/AMO/30399
フルテキストURL fulltext.pdf
著者 Tanaka, Noriaki| Okamoto, Yasuhisa| Gotoh, Kiyotoshi| Hizuta, Akio| Yunoki, Shigeru| Orita, Kunzo|
抄録 <p>The antitumor effects of indomethacin and interleukin 2 (IL-2) were studied in C3H/HeJ mice inoculated with MH134 hepatoma cells. Combined treatment with indomethacin and IL-2 augmented natural killer (NK) cells in mice with MH134-induced peritoneal carcinomatosis, and the survival of the treated mice was significantly longer than the non-treated mice. In animals with subcutaneous MH134 tumors, the combined therapy with indomethacin and IL-2 significantly suppressed tumor growth and induced complete regression of the tumor in three out of five mice. These results suggest that indomethacin and IL-2 therapy could be effective on human gastrointestinal cancer cells as well.</p>
キーワード indomethacin interleukin-2 mouse hepatoma
Amo Type Article
発行日 1995-10
出版物タイトル Acta Medica Okayama
49巻
5号
出版者 Okayama University Medical School
開始ページ 241
終了ページ 245
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 8585394
Web of Sience KeyUT A1995TC51800003