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ID 31651
JaLCDOI
フルテキストURL
著者
Seven, Arzu Istanbul University
Tasan, Ertugrul Istanbul University
Hatemi, Husrev Istanbul University, Turkey
Burcak, Gulden Istanbul University
抄録

This study was performed on 17 hyperthyroid patients and 15 healthy controls. The patients were under propylthiouracil (PTU) therapy at a dosage of 3 x 100 mg/day for one month. Blood samples, taken at the beginning and on the 30th day of therapy, were analyzed for hormonal parameters (T3, T4, TSH), lipid peroxidation endproduct [thiobarbituric acid reactive substances (TBARS)] and antioxidant status parameters: glutathione (GSH), glutathione peroxidase (GSH-Px) and CuZn superoxide dismutase (CuZn SOD). Hyperthyroid patients were observed to have significantly higher TBARS, GSH and CuZn SOD levels than controls (P < 0.05, P < 0.001, P < 0.001, respectively). PTU therapy caused a relief in oxidative stress as reflected by significantly decreased TBARS levels (P < 0.001) and a selective modification in the antioxidant status parameters: significant decreases in GSH and CuZn SOD levels (P < 0.001) and a significant increase in GSH Px (P < 0.01) activity. Our findings suggest a selective modification of the antioxidative profile in hyperthyroidism. PTU should also be considered as an in vivo antioxidant, in addition to its antithyroid action.

キーワード
propylthiouracil
hyperthyroidism
glutathione
glutathione peroxidase
superoxide dismutase
lipid peroxidation
Amo Type
Article
発行日
1999-02
出版物タイトル
Acta Medica Okayama
53巻
1号
出版者
Okayama University Medical School
開始ページ
27
終了ページ
30
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
Web of Sience KeyUT