著者 Taguchi, Hirokuni| Sanada, Hiroshi|
発行日 1974-10
出版物タイトル Acta Medica Okayama
28巻
5号
資料タイプ 学術雑誌論文
著者 Taguchi, Hirokuni| Sanada, Hiroshi| Hara, Koichi| Hasei, Toshio| Iwasaki, Ichiro| Sumitomo, Ryogo|
発行日 1974-04
出版物タイトル Acta Medica Okayama
28巻
2号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/32429
フルテキストURL fulltext.pdf
著者 Takahashi, Isao| Kohi, Fumikazu| Inagaki, Noritoshi| Ohmoto, Eijiro| Fukumoto, Mitsuhiro| Watanabe, Seiichiro| Takaoka, Kazuko| Kitajima, Koichi| Kimura, Ikuro| Sanada, Hiroshi|
抄録 <p>The O2- production by neutrophils was examined in 4 cases of refractory anemia with excess of blasts (RAEB) in order to evaluate the possible causes of enhanced susceptibility to infection and to gain some informations on the differentiation of neutrophils in this hematological disorder. In three of the four RAEB cases there was little O2- production by neutrophils, in addition to there being morphological anomalies of the neutrophils such as a Pelger-Huet-like anomaly, granular deficiency and binucleated cells. These results suggest that the impairment of O2- production by neutrophils in RAEB is one of the possible causes of susceptibility to infection and also suggest that the differentiation of neutrophils in this hematological disorder is faulty. The estimation of O2- production by neutrophils may be a useful diagnostic method for preleukemia.</p>
キーワード superoxide anion refractory anemia with excess of blasts (RAEB) preleukemia
Amo Type Article
発行日 1983-10
出版物タイトル Acta Medica Okayama
37巻
5号
出版者 Okayama University Medical School
開始ページ 417
終了ページ 421
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6316758
Web of Science KeyUT A1983RN98400005
著者 Miyoshi, Isao| Sanada, Hiroshi|
発行日 1962-08
出版物タイトル Acta Medicinae Okayama
16巻
4号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/31932
フルテキストURL fulltext.pdf
著者 Takahishi, Isao| Yorimitsu, Seiichi| Hara, Masamichi| Inagaki, Toshihiro| Nakada, Hiroyuki| Sekito, Noriko| Hayashi, Naoki| Nonaka, kenichi| Ohmoto, Eijiro| Uchida, Kouzaburo| Takizawa, Michihiro| Kimura, Ikuro| Sanada, Hiroshi| Adachi, Tomiro| Tsubota, Teruhiko| Kitajima, Koichi|
抄録 <p>Thirteen previously untreated patients aged 70 and above with acute nonlymphocytic leukemia were treated with aclarubicin (ACR) alone. Among 10 cases (3, acute myelocytic leukemia; 4, acute myelomonocytic leukemia; 2, acute monocytic leukemia; and one, acute erythroleukemia) in which an evaluation was possible, 5 cases (3, acute myelomonocytic leukemia; and 2, acute monocytic leukemia) obtained complete remission (CR). The CR rate was 83% in 6 patients with acute myelomonocytic leukemia or acute monocytic leukemia. The median CR duration and survival was 7.5 and 10 + months, respectively. Although side effects of the drug on digestive system such as nausea, vomiting and anorexia were observed in all patients, they were controllable by conventional treatments. The results suggest that ACR is effective for the clinical management of elderly patients with acute nonlymphocytic leukemia, especially those with acute myelomonocytic leukemia or acute monocytic leukemia.</p>
キーワード acute leukemia in elderly patients chemotherapy of acute leukemia aclarubicin
Amo Type Article
発行日 1986-06
出版物タイトル Acta Medica Okayama
40巻
3号
出版者 Okayama University Medical School
開始ページ 175
終了ページ 177
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 3461685
Web of Science KeyUT A1986C914800006
著者 Seno, Satimaru| Utsumi, Kozo| Awai, Michiyasu| Sanada, Hiroshi|
発行日 1958-10
出版物タイトル Acta Medicinae Okayama
12巻
3号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/31252
フルテキストURL fulltext.pdf
著者 Irino, Shoxo| Sanada, Hiroshi| Maesako, Naohisa| Tanaka, Toshio|
抄録 <p>A 63-year-old man developed generalized lymphadenopathy with skin rashes, fever, hepatomegaly and polyclonal hypergammaglobulinemia, twice, in February 1972 and in June 1979, after taking allopurinol for gout. Cervical lymph node biopsy, performed each time, showed the presence of immunoblasts and plasma cells, effaced nodal structure with involvement of the pericapsular tissue, rich vascularity and numerous mitoses, indicative of angio-immunoblastic lymphadenopathy with dysproteinemia (Frizzera, Moran and Rappaport). The existence of hypersensitivity to drugs, in particular, allopurinol in certain patients was emphasized, and induction of immunoblastic lymphadenopathy with various other therapeutic agents was briefly discussed.</p>
キーワード angio-immunoblastic lymphadenopathy allopurinol.
Amo Type Article
発行日 1981-10
出版物タイトル Acta Medica Okayama
35巻
4号
出版者 Okayama University Medical School
開始ページ 263
終了ページ 272
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6457513
Web of Sience KeyUT A1981MK84200004
JaLCDOI 10.18926/AMO/31037
フルテキストURL fulltext.pdf
著者 Takahashi, Isao| Inagaki, Noritoshi| Nakada, Hiroshi| Ohmoto, Eijiro| Takeuchi, Makoto| Osada, Ken| Matsuzaki, Toshiaki| Fukuda, Shunichi| Uchida, Kozaburo| Kohi, Fumikazu| Yorimitsu, Seiichi| Kimura, Ikuro| Kitajima, Koichi| Sanada, Hiroshi|
抄録 <p>Superoxide anion (O2-) production by neutrophils from 14 untreated patients with acute nonlymphocytic leukemia (ANLL) was significantly less than that of healthy controls (4.93 +/- 1.99 vx 6.20 +/- 1.53 nmol/min/10(6) neutrophils, p less than 0.05). In 10 patients with myelodysplastic syndrome (MDS), however, it was not significantly different from the control level although 6 of the 10 patients had low levels, when individual patients were compared with the lower limit of the control range. An inverse correlation between the O2- production of neutrophils and the percentage of leukemic cells in the marrow existed in ANLL (r = -0.55, p less than 0.01), but not in MDS. Three of 4 MDS patients who died of pneumonia prior to leukemic conversion showed a low level of O2- production. The impaired O2- production by neutrophils from some MDS patients, probably due to the faulty differentiation from leukemic clones, may be one of the causes of enhanced susceptibility to infection.</p>
キーワード superoxide anion production myelodysplastic syndrome preleukemia
Amo Type Article
発行日 1988-02
出版物タイトル Acta Medica Okayama
42巻
1号
出版者 Okayama University Medical School
開始ページ 15
終了ページ 19
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 2834918
Web of Science KeyUT A1988M237800003
JaLCDOI 10.18926/AMO/31015
フルテキストURL fulltext.pdf
著者 Takahashi, Isao| Sekito, Noriko| Takeuchi, Makoto| Osada, Ken| Matsuzaki, Toshiro| Fukuda, Shunichi| Lai, Minyu| Uchida, Kozaburo| Kimura, Ikuro| Miyamoto, Kanji| Kitajima, Koichi| Sanada, Hiroshi|
抄録 <p>The rearrangement of breakpoint cluster region (ber) was examined in leukemic cells obtained from 3 patients initially diagnosed as having Ph+ acute leukemia, 2 with acute lymphocytic leukemia (ALL) and one with acute mixed leukemia. DNA was digested with Bgl II and BamH I. The ber rearrangement was present in the case of acute mixed leukemia (Case 1), but was absent in the 2 cases of ALL (Cases 2 and 3). These results suggest that Case 1 represented a type of blast crisis of chronic myelocytic leukemia which was unusual in the sense of the occurrence of a myeloid-lymphoid conversion and lack of an apparent chronic phase. Cases 2 and 3 appeared to be de novo Ph+ ALL.</p>
キーワード Ph-positive acute leukemia blast crisis with a silent chronic phase myeloidlymphoid conversion chronic myelocytic leukemia bcr-rearrangement
Amo Type Article
発行日 1988-04
出版物タイトル Acta Medica Okayama
42巻
2号
出版者 Okayama University Medical School
開始ページ 117
終了ページ 120
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 3164571
Web of Science KeyUT A1988N237200008
著者 Taguchi, Hirokuni| Sanada, Hiroshi|
発行日 1977-08
出版物タイトル Acta Medica Okayama
31巻
4号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/30705
フルテキストURL fulltext.pdf
著者 Takahashi, Isao| Hara, Masamichi| Uchida, Kozaburo| Takaoka, Kazuko| Watanabe, Seiichiro| Lai, Minyu| Hamasaki, Kazuhide| Kohi, Fumikazu| Kitajima, Koichi| Kimura, Ikuro| Adachi, Tomiro| Yorimitsu, Seiichi| Tokioka, Masaaki| Sanada, Hiroshi|
抄録 <p>Relapses in nine patients with acute myelocytic leukemia were treated with a combination of aclarubicin (ACR) and cytosine arabinoside (ara-C). ACR, 40 mg/m2/day, was administered daily by intravenous injection from day 1 to day 3 and ara-C, 60-80 mg/m2/day, divided into 2 doses, was given every 12 h by intravenous infusion from day 1 to day 7. Depending on the state of the bone marrow, ACR-ara-C regimen was modified in administration period and repeated after the resting periods of at least 7 days. Complete remission was obtained in 7 of 9 patients (77.8%). The time required for achieving the complete remission varied from 20 to 55 days with a median of 39 days. The duration of complete remission was from 8 to 52 weeks with a median of 22 weeks. Side effects on digestive system such as nausea, vomiting and anorexia, were seen in all patients, although they were managed by symptomatic treatment. The results indicate the effectiveness of this ACR-ara-C regimen in the clinical management of acute nonlymphocytic leukemia.</p>
キーワード aclarubicin cytosine arabinoside chemotherapy acute myelocytic leukemia
Amo Type Brief Note
発行日 1982-02
出版物タイトル Acta Medica Okayama
36巻
1号
出版者 Okayama University Medical School
開始ページ 77
終了ページ 80
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6950658
Web of Science KeyUT A1982NE20000009
JaLCDOI 10.18926/AMO/30544
フルテキストURL fulltext.pdf
著者 Takahashi, Isao| Hara, Masamichi| Adachi, Tomiro| Takaoka, Kazuko| Sakano, Makoto| Lai, Miinyuh| Kohi, Fumikazu| Yorimitsu, Seiichi| Tokioka, Masaaki| Kitajima, Koichi| Kimura, Ikuro| Sanada, Hiroshi|
抄録 <p>Twelve patients with refractory acute leukemia (7 patients with acute myelocytic leukemia and 5 patients with acute lymphocytic leukemia) were treated with a new anthracycline antibiotic, aclacinomycin-A (ACM). ACM was administrated by intravenous drip infusion at a dose of 20 mg/day for 7 or 14 days and this was repeated after at least 7 days. Four of 12 patients (33.3%) achieved a complete remission; 3 of 7 acute myelocytic leukemia (42.8%) and 1 of 5 acute lymphocytic leukemia (20.0%). The days required for achieving the complete remission ranged from 23 to 78 days (median: 61) and the total doses of ACM used from 180 to 500 mg (median: 310), and the durations of complete remission from 11 to 28+ weeks (median: 21+). The untoward effects on digestive organs, such as nausea, vomiting and anorexia, and hematological toxicities were frequently seen; however, they were controlled by supportive treatment. Alopecia was not observed. Arrythmia was recognized in one patient at the initiation of ACM infusion with complete remission without withdrawal of ACM. These results suggest that ACM is a potentially effective anthracycline antibiotic in the clinical management of acute leukemia.</p>
キーワード aclacinomycin-A leukemia chemotherapy
Amo Type Brief Note
発行日 1980-11
出版物タイトル Acta Medica Okayama
34巻
5号
出版者 Okayama University Medical School
開始ページ 349
終了ページ 354
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6449134
Web of Science KeyUT A1980KT96800007
JaLCDOI 10.18926/AMO/30519
フルテキストURL fulltext.pdf
著者 Lai, Miinyuh| Hamasaki, Kazuhide| Tokioka, Masaaki| Tsubota, Teruhiko| Nakata, Yasunari| Kitajima, Koichi| Kimura, Ikuro| Sanada, Hiroshi|
抄録 <p>A 30 year old female patient diagnosed as acute lymphoblastic leukemia (ALL) with hand mirror like configuration of lymphoblastic-lymphocytic cells is reported. Although the leukemia was resistant to conventional chemotherapeutic regimens, the patient always looked well and survived for more than 20 months. Surface marker analysis showed that the cell was non-T, non-B, and not reactive to antiserum against common ALL antigen. A cytogenetic study of all the analyzable metaphases of the direct bone marrow preparation had a normal female karyotype. The clinical and hematological course is described. The immunological significance and the influence of hand mirror cell on chemosensitivity and prognosis are discussed.</p>
キーワード acute lymphoblastic leukemia hand mirror cell leukemia.
Amo Type Brief Note
発行日 1980-09
出版物タイトル Acta Medica Okayama
34巻
4号
出版者 Okayama University Medical School
開始ページ 283
終了ページ 287
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6452031
Web of Science KeyUT A1980KK16800007