このエントリーをはてなブックマークに追加
ID 17817
Eprint ID
17817
フルテキストURL
Thumnail 81_505.pdf 1.97 MB
タイトル(別表記)
Electrophysiological and Clinical Studies on Inhibitory Actions of γ-Amino Butyric Acid and its Derivatives Part Ⅰ Electrophysiological Study
著者
菅谷 広司 岡山大学医学部脳神経外科教室
抄録
It is reported that GABA (γ-amino butyric acid) & GABOB (γ-amino β-hydroxy butyric acid) have an inhibitory action to the central nervous system. Recently, S-GABA (γ-amino β-sulfonyl butyric acid) & P-GABA (γ-amino β-phenyl butyric acid) have been composed from GABOB, and reported that they also have an inhibitory action to the convulsive seizure. In the experiments in dogs, P-GABA, S-GABA & GABOB solutions were applied on the cerebral at rest and after discharge caused by electrical stimulation of motor cortex were recorded to examine the anti-convulsive action of these solutions. In the experiments in cats, cortical evoked potentials caused by electrical stimulation of thalamus were recorded to examine the action of GABOB by mearns of computer technique. Furthermore, the application of GABOB & S-GABA solution on the epileptogenic cortical focus of human epileptic was performed and the corticogram was recorded with reference to spikes and after-discharges to examine the anti-convulsive actions of these solutions. The results are following: 1) Application of S-GABA solution on the cerebral cortex caused low voltage activity and spiking activity in corticogram. 2) P-GABA caused spiking activity, developing to the generalized convulsive seizure pattern. 3) These spiking activity caused by S-GABA and P-GABA was, inhibited by GABOB solution. 4) S-GABA did not inhibit the after discharge or spiking activity on the epileptogenic cortical focus of human epileptic. GABOB, however, showed a strong inhibitry action to after discharge & spiking activity. 5) Application of GABOB on the cerebral cortex reversed the cortical evoked potentials caused by electrical stimulation of thalamus. From these findings, it is concluded that GABOB has an inhibitory action on the cerebral cortex, but S-GABA & P-GABA have no inhibitory action.
発行日
1970-03-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
81巻
9-10号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
505
終了ページ
518
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/81/9-10/81_9-10_505/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
OAI-PMH Set
岡山大学
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Sort Key
1
Eprints Journal Name
joma