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ID 17819
Eprint ID
17819
フルテキストURL
Thumnail 81_519.pdf 483 KB
タイトル(別表記)
Electrophysiological and Clinical Studies on Inhibitory Action of γ-Amino Butyric Acid and its Derivatives Part ⅡClinical Study
著者
菅谷 広司 岡山大学医学部脳神経外科教室
抄録
In the experiments in the Part Ⅰ, it has been clarified that GABOB has an inhibitory action to the cerebral cortex and may apply directly on the cerebral cortex without side effect. In this Part Ⅱ, a clinical study has been performed on administration of GABOB into the cerebro-spinal fluid cavity. One is the application of GABOB to the intradural cavity during craniotomy of brain tumor to prevent the postoperative convulsions, and the other is the intrathecal and intraventricular administration of GABOB when postoperative convulsions occur. For the purpose of preventing the postoperative convulsions after craniotomy, 100 mg of GABOB was applied on the cerebral surface during craniotomy in 293 cases of brain tumor. Except for operative deaths, a comparison of the postoperative convulsions was made between the GABOB group and the control group. 1) The occurrence of postoperative convulsions was decreased in the GABOB group. 2) In the GABOB group, the onset of postoperative convulsions was later than that of the control group. 3) Frequency of postoperative convulsions was decreased in the GABOB group, and majority of the cases showed only one seizure. 4) Administration of GABOB into the intradural cavity showed no side effect. There were 14 cases of postoperative convulsive state. Application of GABOB into the intraventricular or intrathecal cavity was effective to inhibit convulsive state in all cases without any side effect. From the these results, it is recognized that application of GABOB into the cerebro-spinal fluid cavity is most effective method to the prevention and treatment of the postoperative convulsions.
発行日
1970-03-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
81巻
9-10号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
519
終了ページ
526
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/81/9-10/81_9-10_519/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
OAI-PMH Set
岡山大学
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Sort Key
2
Eprints Journal Name
joma