| ID | 56202 |
| フルテキストURL | |
| 著者 |
Takamura, Hiroyoshi
Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
Kaken ID
researchmap
Katsube, Tomoya
Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
Okamoto, Kazuki
Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
Kadota, Isao
Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
|
| 抄録 | The first total synthesis of two possible diastereomers of natural 6-chlorotetrahydrofuran acetogenin 1 has been achieved. The synthetic route features 5-exo-tet cyclization, Z selective Wittig reaction and Julia olefination for the construction of conjugated diene and enyne moieties, and stereoselective chlorination. Comparison of their 1 H and 13 C NMR data and specific rotation with those of the natural product elucidated the absolute configuration of natural (-)-6-chlorotetrahydrofuran acetogenin 1.
|
| キーワード | natural products
stereoselective synthesis
structure elucidation
tetrahydrofuran
total synthesis
|
| 備考 | This is an article published by Wiley‐VCH
|
| 発行日 | 2017-12-06
|
| 出版物タイトル |
Chemistry - A European Journal
|
| 巻 | 23巻
|
| 号 | 68号
|
| 出版者 | Wiley‐VCH
|
| 開始ページ | 17191
|
| 終了ページ | 17194
|
| ISSN | 09476539
|
| NCID | AA11076269
|
| 資料タイプ |
学術雑誌論文
|
| 言語 |
English
|
| OAI-PMH Set |
岡山大学
|
| 著作権者 | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
|
| 論文のバージョン | author
|
| PubMed ID | |
| DOI | |
| Web of Science KeyUT | |
| 関連URL | isVersionOf https://doi.org/10.1002/chem.201703234
|
