JaLCDOI 10.18926/AMO/55305
フルテキストURL 71_4_291.pdf
著者 Naganuma, Atsushi| Hoshino, Takashi| Suzuki, Yuhei| Uehara, Daisuke| Kudo, Tomohiro| Ishihara, Hiroshi| Sato, Ken| Kakizaki, Satoru| Yamada, Masanobu| Takagi, Hitoshi|
抄録 The effect of skeletal muscle mass (SMM) on the outcomes of sorafenib treatment for hepatocellular carcinoma (HCC) has not been established. We measured the SMM in HCC patients treated with sorafenib, evaluated the patients’ survival, and evaluated the association between skeletal muscle depletion and sorafenib treatment. Of the 97 HCC patients treated with sorafenib at our institution in the period from July 2009 to February 2015, our study included 69 patients (51 males, 18 females) who had received sorafenib for ≥ 8 weeks and whose follow-up data were available. SMM was calculated from computed tomography images at the mid-L3 level (cm2) and normalized to height (m2) to yield the L3 skeletal muscle index (L3-SMI, cm2/m2). The median L3-SMI value was higher in the males (43 cm2/m2) compared to the females (36 cm2/m2). In the males only, the multivariate Cox regression identified an L3-SMI <43 cm2/m2 as independently associated with higher mortality compared to an L3-SMI ≥43 cm2/m2 (hazard ratio 2.315, 95% confidence interval: 1.125-4.765, p=0.023). Skeletal muscle depletion is a factor predicting poor prognosis for male patients with advanced HCC treated with sorafenib.
キーワード skeletal muscle depletion hepatocellular carcinoma sorafenib L3 skeletal muscle index prognostic factor
Amo Type Original Article
発行日 2017-08
出版物タイトル Acta Medica Okayama
71巻
4号
出版者 Okayama University Medical School
開始ページ 291
終了ページ 299
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2017 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 28824184
JaLCDOI 10.18926/AMO/32880
フルテキストURL fulltext.pdf
著者 Onozato, Yasuhiro| Kakizaki, Satoru| Iizuka, Haruhisa| Mori, Kazuyo| Takizawa, Daichi| Ohyama, Tatsuya| Arakawa, Kazuhisa| Arai, Hirotaka| Ishihara, Hiroshi| Abe, Takehiko| Sohara, Naondo| Sato, Ken| Takagi, Hitoshi| Mori, Masatomo|
抄録 <p>The term &#34;ectopic varices&#34; is used to describe dilated portosystemic collateral veins in unusual locations other than the gastroesophageal region. We recently experienced a rare case of ectopic varices that developed in the gastroduodenal anastomosis after subtotal gastrectomy. A 70-year-old male with liver cirrhosis due to hepatitis C virus infection was admitted for hematemesis and tarry stool. He had received a subtotal gastrectomy with the Billroth-I method for gastric ulcer at 46 years of age. Although emergency endoscopy revealed esophageal and gastric fundal varices, there were no obvious bleeding points. After removal of the coagula, ectopic varices and a fibrin plug were observed on the gastroduodenal anastomosis. During the observation, blood began to spurt from the fibrin plug. N-butyl-2-cyanoacrylate with lipiodol injection succeeded in hemostasis. Splenic angiography showed gastric varices feeding from a short gastric vein and the posterior gastric vein. The blood flow around the bleeding point, as indicated by lipiodol deposition, had decreased, and no feeding vein was observed. Endoscopic and angiographic findings are shown and the treatment for such lesions is discussed.</p>
キーワード ectopic varices N-butyl-2-cyanoacrylate (Histoacryl) gastroduodenal anastomosis portal hypertension
Amo Type Case Report
発行日 2007-12
出版物タイトル Acta Medica Okayama
61巻
6号
出版者 Okayama University Medical School
開始ページ 361
終了ページ 365
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 18183082
Web of Sience KeyUT 000251943800008
JaLCDOI 10.18926/AMO/30716
フルテキストURL fulltext.pdf
著者 Matsui, Masayuki| Kojima, Akira| Kakizaki, Satoru| Nagasaki, Kazumi| Sohara, Naondo| Sato, Ken| Takagi, Hitoshi| Mori, Masatomo| Ohno, Yoshihiro|
抄録 The term ectopic varices is used to describe dilated portosystemic collateral veins in unusual locations other than the gastroesophageal region. We recently experienced a rare case of ectopic varices that developed in the right diaphragm and ruptured into the pleural cavity. A 68-year-old female with hepatocellular carcinoma complicated with liver cirrhosis was admitted due to an acute onset of dyspnea and right bloody pleural effusion. Because of the patient's advanced hepatocellular carcinoma and poor condition, conservative therapies such as hemostats and blood transfusion were selected. Even though the bleeding to the pleural cavity stopped spontaneously, the patient died due to a progression of liver failure. Autopsy revealed a huge collateral vein in the right diaphragm. The etiology, prevalence, relationship with portal hypertension, and treatment of ectopic varices are discussed herein.
キーワード ectopic varices portal hypertension collateral vein diaphragm
Amo Type Article
発行日 2006-08
出版物タイトル Acta Medica Okayama
60巻
4号
出版者 Okayama University Medical School
開始ページ 229
終了ページ 232
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 16943860
Web of Sience KeyUT 000239911100004
JaLCDOI 10.18926/AMO/30713
フルテキストURL fulltext.pdf
著者 Teshigawara, Katsunobu| Kakizaki, Satoru| Sohara, Naondo| Hashida, Tetsu| Tomizawa, Yoshio| Sato, Ken| Takagi, Hitoshi| Mori, Masatomo| Hoshino, Keiko| Mogi, Kenji|
抄録 Oral metastases from hepatocellular carcinoma are very rare. We encountered a case of hepatocellular carcinoma with a solitary metastasis to the mandible as an initial manifestation. The patient was a 76-year-old man who was admitted for left mandibular swelling. A biopsy specimen of mandible was suspected to be a metastatic tumor. The histological findings, abdominal computed tomography, bone scintigraphy, and F-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) revealed it to be a solitary metastasis from hepatocellular carcinoma. As a result, he was diagnosed to have liver cirrhosis due to a hepatitis C virus infection and hepatocellular carcinoma with a solitary metastasis to the mandible. The primary lesion was treated with transcatheter arterial embolization (TAE), and the metastasis to the mandible was surgically resected. The patient survived for 9 months after treatment without recurrence.
キーワード hepatocellular carcinoma mandibular metastasis oral metastasis
Amo Type Article
発行日 2006-08
出版物タイトル Acta Medica Okayama
60巻
4号
出版者 Okayama University Medical School
開始ページ 243
終了ページ 247
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 16943863
Web of Sience KeyUT 000239911100007