著者 Takahashi, Isao| Sakato, Junya| Mikochi, Hiroshi| Moriwaki, Hiroshi| Kitajima, Koichi| Irino, Shozo| Hiraki, Kiyoshi|
発行日 1974-08
出版物タイトル Acta Medica Okayama
28巻
4号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/32429
フルテキストURL fulltext.pdf
著者 Takahashi, Isao| Kohi, Fumikazu| Inagaki, Noritoshi| Ohmoto, Eijiro| Fukumoto, Mitsuhiro| Watanabe, Seiichiro| Takaoka, Kazuko| Kitajima, Koichi| Kimura, Ikuro| Sanada, Hiroshi|
抄録 <p>The O2- production by neutrophils was examined in 4 cases of refractory anemia with excess of blasts (RAEB) in order to evaluate the possible causes of enhanced susceptibility to infection and to gain some informations on the differentiation of neutrophils in this hematological disorder. In three of the four RAEB cases there was little O2- production by neutrophils, in addition to there being morphological anomalies of the neutrophils such as a Pelger-Huet-like anomaly, granular deficiency and binucleated cells. These results suggest that the impairment of O2- production by neutrophils in RAEB is one of the possible causes of susceptibility to infection and also suggest that the differentiation of neutrophils in this hematological disorder is faulty. The estimation of O2- production by neutrophils may be a useful diagnostic method for preleukemia.</p>
キーワード superoxide anion refractory anemia with excess of blasts (RAEB) preleukemia
Amo Type Article
発行日 1983-10
出版物タイトル Acta Medica Okayama
37巻
5号
出版者 Okayama University Medical School
開始ページ 417
終了ページ 421
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6316758
Web of Sience KeyUT A1983RN98400005
著者 Takahashi, Isao|
発行日 1940-03
出版物タイトル Arbeiten aus der Medizinischen Fakultät zu Okayama
6巻
3号
資料タイプ 学術雑誌論文
著者 Takahashi, Isao|
発行日 1940-03
出版物タイトル Arbeiten aus der Medizinischen Fakultät zu Okayama
6巻
3号
資料タイプ 学術雑誌論文
著者 Takahashi, Isao|
発行日 1940-03
出版物タイトル Arbeiten aus der Medizinischen Fakultät zu Okayama
6巻
3号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/32175
フルテキストURL fulltext.pdf
著者 Takahashi, Isao| Sano, Masayuki| Okamoto, Hideyuki| Shiromoto, Masayoshi| Nakamura, Toru| Ueno, Katsumi| Nakada, Hiroshi| Haruta, Yuro| Seto, Takumi| Yamashita, Jiro| Yorimitsu, Seiichi| Miyake, Susumu| Machida, Kenichi| Konda, Keiji| Tamura, Tetuo| Imajou, Kenji| Kimura, Ikuro|
抄録 <p>A 34-year-old woman infected with human T cell leukemia virus type-I(HTLV-I) with recurrent thrombocytopenia and various autoantibodies is described. The platelet counts fluctuated between 1.3 x 10(4)/microliters and 14.8 x 10(4)/microliters without any medical treatment, and thrombocytopenia improved with a decrease of platelet-associated IgG (PA-IgG). Autoantibodies such as rheumatoid factor, antinuclear factor, anti-Sm, anti-RNP and anti-SSA antibodies were also recognized. Marker analysis of peripheral mononuclear cells showed an increase in the proportion of CD 25+ cells, CD 3+ HLA-DR+ cells, CD4+ HLA-DR+ cells and CD8+ HLA-DR+ cells. The recurrent thrombocytopenia and development of various autoantibodies in this HTLV-I carrier are speculated to be due to the alteration of B cell functions by T cells infected with HTLV-I.</p>
キーワード recurrent thrombocytopenia HTLV-I HTLV-I carier
Amo Type Article
発行日 1991-12
出版物タイトル Acta Medica Okayama
45巻
6号
出版者 Okayama University Medical School
開始ページ 445
終了ページ 449
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 1781301
Web of Sience KeyUT A1991GX45300007
JaLCDOI 10.18926/AMO/31624
フルテキストURL fulltext.pdf
著者 Mizobuchi, Noriko| Takahashi, Isao| Yorimitsu, Seiichi| Horimi, Tadashi| Hamada, Kyoko| Matsuoka, Misuzu| Sonobe, Hiroshi| Hiroi, Makoto| Kubonishi, Ichiro|
抄録 <p>A new myeloid cell line, MTT-95, was established from the bone marrow of a patient with acute myelogenous leukemia (AML, M7). MTT-95 cells differentiate into mature basophilic cells in culture medium with no chemical component or cytokine. Surface phenotypes were as follows: CD11b 79.3%, CD13 92.4%, CD33 99.8%, CD34 87.9%, CD41a 77.6% and HLA-DR 0.3%. MTT-95 cells were strongly positive for glycoprotein IIb/IIIa by immunohistochemical staining and revealed metachromatic granules. MTT-95 cells seem to possess characteristics of both megakaryocytes and basophils. These findings suggest that MTT-95 cells are basophil progenitors. MTT-95 cells might be useful in the study not only of the biological aspects of basophils, but also of the diversities of AML (M7).</p>
キーワード myeloid cell line acute myelogenous leukemia basophil megakaryocyte
Amo Type Article
発行日 1999-04
出版物タイトル Acta Medica Okayama
53巻
2号
出版者 Okayama University Medical School
開始ページ 95
終了ページ 98
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
Web of Sience KeyUT 000080058700006
JaLCDOI 10.18926/AMO/31506
フルテキストURL fulltext.pdf
著者 Takahashi, Isao| Ohmoto, Eijiro| Aoyaka, Shigeo| Takizawa, Michihiro| Oda, Yasuhiro| Nonaka, Kenichi| Nakada, Hiroyuki| Yorimitsu, Seiichi|
抄録 <p>Age-related alterations in the host defense system have been vigorously investigated because of increased susceptibility to infection and neoplasms in the aged. Although monocyte-macrophages form a major part of the cellular defense against microorganisms, the majority of investigations has been limited to neutrophils and lymphocytes. The present study, designed to determine the influence of age on mononuclear phagocytes, revealed no significant decrease in the absolute number of blood monocytes, but did reveal a tendency for the chemiluminescence of blood monocytes to decrease (p less than 0.10) and a significant decrease in the numbers of macrophage precursors (p less than 0.05) in the aged (over 70 year old), in comparison with controls (under 40 years old). On the basis of these findings, functional alterations of monocyte-macrophages seem to participate in the increased susceptibility to infection in the aged.</p>
キーワード monocyte chemiluminescence macrophage precursor monocyte function in the aged susceptibility to infection in the aged
Amo Type Article
発行日 1985-12
出版物タイトル Acta Medica Okayama
39巻
6号
出版者 Okayama University Medical School
開始ページ 447
終了ページ 451
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 4091040
Web of Sience KeyUT A1985AWT4000004
JaLCDOI 10.18926/AMO/31037
フルテキストURL fulltext.pdf
著者 Takahashi, Isao| Inagaki, Noritoshi| Nakada, Hiroshi| Ohmoto, Eijiro| Takeuchi, Makoto| Osada, Ken| Matsuzaki, Toshiaki| Fukuda, Shunichi| Uchida, Kozaburo| Kohi, Fumikazu| Yorimitsu, Seiichi| Kimura, Ikuro| Kitajima, Koichi| Sanada, Hiroshi|
抄録 <p>Superoxide anion (O2-) production by neutrophils from 14 untreated patients with acute nonlymphocytic leukemia (ANLL) was significantly less than that of healthy controls (4.93 +/- 1.99 vx 6.20 +/- 1.53 nmol/min/10(6) neutrophils, p less than 0.05). In 10 patients with myelodysplastic syndrome (MDS), however, it was not significantly different from the control level although 6 of the 10 patients had low levels, when individual patients were compared with the lower limit of the control range. An inverse correlation between the O2- production of neutrophils and the percentage of leukemic cells in the marrow existed in ANLL (r = -0.55, p less than 0.01), but not in MDS. Three of 4 MDS patients who died of pneumonia prior to leukemic conversion showed a low level of O2- production. The impaired O2- production by neutrophils from some MDS patients, probably due to the faulty differentiation from leukemic clones, may be one of the causes of enhanced susceptibility to infection.</p>
キーワード superoxide anion production myelodysplastic syndrome preleukemia
Amo Type Article
発行日 1988-02
出版物タイトル Acta Medica Okayama
42巻
1号
出版者 Okayama University Medical School
開始ページ 15
終了ページ 19
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 2834918
Web of Sience KeyUT A1988M237800003
JaLCDOI 10.18926/AMO/31015
フルテキストURL fulltext.pdf
著者 Takahashi, Isao| Sekito, Noriko| Takeuchi, Makoto| Osada, Ken| Matsuzaki, Toshiro| Fukuda, Shunichi| Lai, Minyu| Uchida, Kozaburo| Kimura, Ikuro| Miyamoto, Kanji| Kitajima, Koichi| Sanada, Hiroshi|
抄録 <p>The rearrangement of breakpoint cluster region (ber) was examined in leukemic cells obtained from 3 patients initially diagnosed as having Ph+ acute leukemia, 2 with acute lymphocytic leukemia (ALL) and one with acute mixed leukemia. DNA was digested with Bgl II and BamH I. The ber rearrangement was present in the case of acute mixed leukemia (Case 1), but was absent in the 2 cases of ALL (Cases 2 and 3). These results suggest that Case 1 represented a type of blast crisis of chronic myelocytic leukemia which was unusual in the sense of the occurrence of a myeloid-lymphoid conversion and lack of an apparent chronic phase. Cases 2 and 3 appeared to be de novo Ph+ ALL.</p>
キーワード Ph-positive acute leukemia blast crisis with a silent chronic phase myeloidlymphoid conversion chronic myelocytic leukemia bcr-rearrangement
Amo Type Article
発行日 1988-04
出版物タイトル Acta Medica Okayama
42巻
2号
出版者 Okayama University Medical School
開始ページ 117
終了ページ 120
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 3164571
Web of Sience KeyUT A1988N237200008
著者 Takahashi, Isao| Nakanishi, Toshio| Sakato, Junya| Mikochi, Hiroshi| Kitajima, Koichi| Hiraki, Kiyoshi|
発行日 1975-12
出版物タイトル Acta Medica Okayama
29巻
6号
資料タイプ 学術雑誌論文
著者 Takahashi, Isao| Mikochi, Hiroshi| Sakato, Junya| Nakanishi, Toshio| Toki, Hironobu| Kamimura, Okinobu| Kitajima, Koichi|
発行日 1975-08
出版物タイトル Acta Medica Okayama
29巻
4号
資料タイプ 学術雑誌論文
著者 Toki, Hironobu| Takahashi, Yasuhiko| Nakanishi, Norio| Naito, Tokuo| Chen, Pomin| Takahashi, Isao| Kitajima, Koichi|
発行日 1977-02
出版物タイトル Acta Medica Okayama
31巻
1号
資料タイプ 学術雑誌論文
著者 Toki, Hironobu| Kitajima, Koichi| Takahashi, Isao| Tokioka, Masaaki| Kitagawa, Nakayuki| Koi, Fumikazu| Kimura, Ikuro|
発行日 1977-08
出版物タイトル Acta Medica Okayama
31巻
4号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/30761
フルテキストURL fulltext.pdf
著者 Mizobuchi, Noriko| Takahashi, Isao| Horimi, Tadashi| Yamamoto, Megumi| Hamada, Kyoko| Yorimitsu, Seiichi| Kubonishi, Ichiro|
抄録 <p>A new myeloid cell line, MTO-94, was established from the bone marrow of a patient with myelodysplastic syndrome (MDS). MTO-94 cells matured in culture medium without the addition of growth factors, and yielded neutrophils with pseudo-Pelger Hue&#776;t anomaly or hypersegmentation until 6 months. Ten months after the start of cell cultivation, MTO-94 consisted of myeloblasts. Surface phenotypes were as follows: CD7 90.3%, CD13 99.6%, CD33 75.6%, HLA-DR 96.3% and CD34 0.9%. The karyotype was 46, XY, i(17q). The proliferation of MTO-94 cells was enhanced by rhlL-3, G-CSF, rhGM-CSF and rhSCF but not by rhlL-6 and erythropoietin. MTO-94 cells with i(17q) might be useful in the study of biological aspects of not only MDS, but also hematological malignancies with i(17q) as the sole chromosomal anomaly.</p>
キーワード isochromosome 17q myeloid cell line myelodysplastic syndrome
Amo Type Article
発行日 1997-08
出版物タイトル Acta Medica Okayama
51巻
4号
出版者 Okayama University Medical School
開始ページ 227
終了ページ 232
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 9284971
Web of Sience KeyUT A1997XU03200007
JaLCDOI 10.18926/AMO/30707
フルテキストURL fulltext.pdf
著者 Adachi, Tomiroh| Asano, Kenwo| Sezaki, Tatsuo| Takahashi, Isao| Kimura, Ikuro|
抄録 <p>Response rates and survival times were studied in 47 patients who had multiple myeloma and who were being treated with Prednisolone and sequential Melphalan and Ifosfamide (MIP therapy). The clinical response was determined by objective parameters such as the reduction of M-protein level, tumor volume and healing of bone destruction. Twenty-eight of the patients (59.6%) responded to the MIP therapy. The 50% survival time as followed from the initiation of treatment to death was 19 months. Of the prognostic factors, the age (greater than or equal to 70 years), clinical stage III of Durie and Salmon, hypercalcemia, extensive bone lesions, and the patho-morphological type IV of Brucher were associated with a decreased life-span. Therefore, MIP therapy was more effective in poor risk (high tumor mass group) than in good risk (low or intermediate tumor mass group) patients, but the survival of patients on MIP therapy was shorter in the poor risk group than in the good risk one. In addition, the group which responded rapidly (i.e. within 2-5 weeks) had longer remission and longer survival than the group which improved slowly (i.e. after 6-16 weeks).</p>
キーワード multiple myeloma prognostic factor combination chemotherapy
Amo Type Article
発行日 1982-02
出版物タイトル Acta Medica Okayama
36巻
1号
出版者 Okayama University Medical School
開始ページ 39
終了ページ 47
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 7064732
Web of Sience KeyUT A1982NE20000004
JaLCDOI 10.18926/AMO/30705
フルテキストURL fulltext.pdf
著者 Takahashi, Isao| Hara, Masamichi| Uchida, Kozaburo| Takaoka, Kazuko| Watanabe, Seiichiro| Lai, Minyu| Hamasaki, Kazuhide| Kohi, Fumikazu| Kitajima, Koichi| Kimura, Ikuro| Adachi, Tomiro| Yorimitsu, Seiichi| Tokioka, Masaaki| Sanada, Hiroshi|
抄録 <p>Relapses in nine patients with acute myelocytic leukemia were treated with a combination of aclarubicin (ACR) and cytosine arabinoside (ara-C). ACR, 40 mg/m2/day, was administered daily by intravenous injection from day 1 to day 3 and ara-C, 60-80 mg/m2/day, divided into 2 doses, was given every 12 h by intravenous infusion from day 1 to day 7. Depending on the state of the bone marrow, ACR-ara-C regimen was modified in administration period and repeated after the resting periods of at least 7 days. Complete remission was obtained in 7 of 9 patients (77.8%). The time required for achieving the complete remission varied from 20 to 55 days with a median of 39 days. The duration of complete remission was from 8 to 52 weeks with a median of 22 weeks. Side effects on digestive system such as nausea, vomiting and anorexia, were seen in all patients, although they were managed by symptomatic treatment. The results indicate the effectiveness of this ACR-ara-C regimen in the clinical management of acute nonlymphocytic leukemia.</p>
キーワード aclarubicin cytosine arabinoside chemotherapy acute myelocytic leukemia
Amo Type Brief Note
発行日 1982-02
出版物タイトル Acta Medica Okayama
36巻
1号
出版者 Okayama University Medical School
開始ページ 77
終了ページ 80
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6950658
Web of Sience KeyUT A1982NE20000009
JaLCDOI 10.18926/AMO/30544
フルテキストURL fulltext.pdf
著者 Takahashi, Isao| Hara, Masamichi| Adachi, Tomiro| Takaoka, Kazuko| Sakano, Makoto| Lai, Miinyuh| Kohi, Fumikazu| Yorimitsu, Seiichi| Tokioka, Masaaki| Kitajima, Koichi| Kimura, Ikuro| Sanada, Hiroshi|
抄録 <p>Twelve patients with refractory acute leukemia (7 patients with acute myelocytic leukemia and 5 patients with acute lymphocytic leukemia) were treated with a new anthracycline antibiotic, aclacinomycin-A (ACM). ACM was administrated by intravenous drip infusion at a dose of 20 mg/day for 7 or 14 days and this was repeated after at least 7 days. Four of 12 patients (33.3%) achieved a complete remission; 3 of 7 acute myelocytic leukemia (42.8%) and 1 of 5 acute lymphocytic leukemia (20.0%). The days required for achieving the complete remission ranged from 23 to 78 days (median: 61) and the total doses of ACM used from 180 to 500 mg (median: 310), and the durations of complete remission from 11 to 28+ weeks (median: 21+). The untoward effects on digestive organs, such as nausea, vomiting and anorexia, and hematological toxicities were frequently seen; however, they were controlled by supportive treatment. Alopecia was not observed. Arrythmia was recognized in one patient at the initiation of ACM infusion with complete remission without withdrawal of ACM. These results suggest that ACM is a potentially effective anthracycline antibiotic in the clinical management of acute leukemia.</p>
キーワード aclacinomycin-A leukemia chemotherapy
Amo Type Brief Note
発行日 1980-11
出版物タイトル Acta Medica Okayama
34巻
5号
出版者 Okayama University Medical School
開始ページ 349
終了ページ 354
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6449134
Web of Sience KeyUT A1980KT96800007
JaLCDOI 10.18926/AMO/30448
フルテキストURL fulltext.pdf
著者 Haruta, Yuro| Takahashi, Isao| Sekito, Noriko| Miyamoto, Kanji| Shimamoto, Masaaki| Wakita, Yoshiharu| Kikkawa, Kiyoshi| Nakamura, Toru| Seto, Takumi| Yamashita, Jiro| Yorimiysu, Seiichi| Miyake, Susumu| Machida, Ken-ichi| Kimura, Ikuro|
抄録 <p>A rare case of variant Philadelphia (Ph1) chromosome positive [46, XX, t (9; 22) (q34; q11), inv (9) (9q22; 22q13)] chronic myelocytic leukemia (CML) was described. The patient, 73 years old female, was hospitalized to our hospital because of leukocytosis. Hematological findings corresponded to those of CMLs. However, this case lacked hepatosplenomegaly. Southern blot analysis using a 3 breakpoint cluster region (bcr) probe revealed a bcr rearrangement. The patient has been in the chronic phase for sixteen months without treatment. Clinical and chromosomal changes are under observation in order to get accumulate data for a pathophysiological analysis of variant Ph1 positive CMLs.</p>
キーワード variant Ph1 positive chronic myelocytic leukemia bcr rearrangement
Amo Type Article
発行日 1990-10
出版物タイトル Acta Medica Okayama
44巻
5号
出版者 Okayama University Medical School
開始ページ 283
終了ページ 286
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 2260501
Web of Sience KeyUT A1990EG00700009
JaLCDOI 10.18926/AMO/30435
フルテキストURL fulltext.pdf
著者 Takahashi, Isao| Hayashi, Naoki| Nakamura, Toru| Matuzaki, Toshiro| Murase, Toshio| Osada, Ken| Takeuchi, Makoto| Ueki, Yasufumi| Nakada, Hiroshi| Yorimitsu, Seiichi| Kimura, Ikuro|
抄録 <p>The effects of uridine(UR) on the cell-killing activity of cytosine arabinoside(ara-C) against human leukemic cells, MOLT-4, and on ara-C accumulation in cells were studied. The 50% lethal dose(LD50) of ara-C as determined by clonogenic assay was decreased to 5.0 x 10(-8) mol from 9.0 x 10(-7) mol after 3 days exposure to 10(-3) mol of UR. The accumulation of 3H-ara-C at 24 and 48 h was significantly increased in culture medium containing 10(-8) mol of 3H-ara-C and 10(-3) mol of UR (5,129 +/- 123.5 vs 2,554 +/- 115.5 cpm/10(5) cells at 24 h, p less than 0.01, and 5,772 +/- 123.2 vs 1,372 +/- 51.8 cpm/10(5) cells at 48 h, p less than 0.01). It is noteworthy that cell-killing activity of ara-C against human leukemic cells was enhanced by the combination with a nucleoside(UR), but not with antileukemic agents.</p>
キーワード cytosine arabinosids uridine antileukemic effect accumulation of cytosine arabinoside
Amo Type Article
発行日 1990-12
出版物タイトル Acta Medica Okayama
44巻
6号
出版者 Okayama University Medical School
開始ページ 329
終了ページ 331
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 2075831
Web of Sience KeyUT A1990EP70700008