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ID 32429
JaLCDOI
フルテキストURL
著者
Takahashi, Isao Okayama University
Kohi, Fumikazu Okayama University
Inagaki, Noritoshi Okayama University
Ohmoto, Eijiro Okayama University
Fukumoto, Mitsuhiro Okayama University
Watanabe, Seiichiro Okayama University
Takaoka, Kazuko Okayama University
Kitajima, Koichi Okayama University
Kimura, Ikuro Okayama University
Sanada, Hiroshi Okayama University
抄録

The O2- production by neutrophils was examined in 4 cases of refractory anemia with excess of blasts (RAEB) in order to evaluate the possible causes of enhanced susceptibility to infection and to gain some informations on the differentiation of neutrophils in this hematological disorder. In three of the four RAEB cases there was little O2- production by neutrophils, in addition to there being morphological anomalies of the neutrophils such as a Pelger-Huet-like anomaly, granular deficiency and binucleated cells. These results suggest that the impairment of O2- production by neutrophils in RAEB is one of the possible causes of susceptibility to infection and also suggest that the differentiation of neutrophils in this hematological disorder is faulty. The estimation of O2- production by neutrophils may be a useful diagnostic method for preleukemia.

キーワード
superoxide anion
refractory anemia with excess of blasts (RAEB)
preleukemia
Amo Type
Article
発行日
1983-10
出版物タイトル
Acta Medica Okayama
37巻
5号
出版者
Okayama University Medical School
開始ページ
417
終了ページ
421
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT