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ID 17805
Eprint ID
17805
フルテキストURL
Thumnail 84_1.pdf 1.03 MB
タイトル(別表記)
Significance of basophilic leukocytes in reagin-type allergy
著者
木村 郁郎 岡山大学医学部平木内科
守谷 欣明 岡山大学医学部平木内科
谷崎 勝朗 岡山大学医学部平木内科
斉藤 勝剛 岡山大学医学部平木内科
高橋 清 岡山大学医学部平木内科
抄録
Changes of basophils in peripheral blood were observed in 201 patients with bronchial asthma. And this study is concerned with the threshold of asthmatic attack indicated by basophils and the relationship between basophils and reagin-type antibody-antigen reaction. The results show that the basophils increase before the attack in an episode of asthmatic attack. The threshold of asthmatic attack indicated by basophil count of 65/cmm is very significant for the observation of asthmatic attack, and it is possible to expect a next attack in the pre-attack stage, if the basophil tends to increase over this value. And this threshold of asthmatic attack was constant in individual cases. These changes of basophils were similar in the cases given steroid hormone. In eosinophils these changes were not so clear-cut. In a prolonged therapeutic course basophils in bronchial asthma were shown over the threshold in the stage of repeated asthmatic attacks, and lower in the non-attack stage reflecting the therapeutic effect. It was also found that basophils increased clearly in patients with sea-squirt asthma who showed positive Prausnitz-Kustner reaction. This result indicates that there is a close relation between basophils and reaginic antibody-antigen reaction. The action of heparin contained in basophils concerned with the mechanism of allergic reaction of reagin-type was examined. And it was observed that heparin suppressed the allergic reaction caused by reaginic antibody in the rat, and was an antagonist for histamine. Therefore, it was considered that one of the roles of basophilic leukocytes is to repair the reaction of reagin-type allergy.
発行日
1972-02-28
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
84巻
1-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1
終了ページ
10
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/84/1-2/84_1-2_1/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
OAI-PMH Set
岡山大学
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Sort Key
1
Eprints Journal Name
joma