start-ver=1.4
cd-journal=joma
no-vol=60
cd-vols=
no-issue=6
article-no=
start-page=325
end-page=330
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2006
dt-pub=200612
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Study of interleukin-6 in the spread of colorectal cancer: the diagnostic significance of IL-6.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We investigated the diagnostic significance of IL-6 for lymph node metastasis and/or hepatic metastasis from colorectal cancer in 65 patients and evaluated the contributions of 8 factors (IL-6, HGF, IL-1beta, TNF-alpha, TGF-beta1, ELAM-1, ICAM-1, VCAM-1) toward Dukes.s classification of 53 patients. We also examined IL-6 expression in tumor tissue. From the receiver operating characteristic (ROC) curve analysis, an optimal cutoff value of 5.8 pg/ml was determined to classify lymph node and/or hepatic metastasis, and that of 6.3 pg/ml was determined to classify hepatic metastasis. These values indicated sensitivities of 55.0% and 71.4%, and specifi cities of 100% and 88.6%, respectively. IL-6, HGF, and ELAM-1 were very useful for distinguishing among Dukes.s A/B group, C group, and D group. In all cases with high IL-6 values (more than 25.0 pg/ml), immunohistochemical staining was positive for IL-6 in the cytoplasm of cancer cells. IL-6 is strongly suspected to be involved in lymph node and/or hepatic metastasis by promoting it through HGF, and serum IL-6 value (pg/ml) would be useful diagnostically to estimate whether or not there is a high risk of lymph node and/or hepatic metastasis.
en-copyright=
kn-copyright=

en-aut-name=AshizawaTatsuto
en-aut-sei=Ashizawa
en-aut-mei=Tatsuto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OkadaRyosuke
en-aut-sei=Okada
en-aut-mei=Ryosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SuzukiYoshiaki
en-aut-sei=Suzuki
en-aut-mei=Yoshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakagiMakoto
en-aut-sei=Takagi
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YamazakiTatsuyuki
en-aut-sei=Yamazaki
en-aut-mei=Tatsuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SumiTetsuo
en-aut-sei=Sumi
en-aut-mei=Tetsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=AokiToshiaki
en-aut-sei=Aoki
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=AokiTatsuya
en-aut-sei=Aoki
en-aut-mei=Tatsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=
kn-affil=Tokyo Medical University Hachioji Medical Center, Tokyo

affil-num=2
en-affil=
kn-affil=Tokyo Medical University Hachioji Medical Center, Tokyo

affil-num=3
en-affil=
kn-affil=Tokyo Medical University Hachioji Medical Center, Tokyo

affil-num=4
en-affil=
kn-affil=Tokyo Medical University Hachioji Medical Center, Tokyo

affil-num=5
en-affil=
kn-affil=Tokyo Medical University Hachioji Medical Center, Tokyo

affil-num=6
en-affil=
kn-affil=Tokyo Medical University Hachioji Medical Center, Tokyo

affil-num=7
en-affil=
kn-affil=Tokyo Medical University Hachioji Medical Center, Tokyo

affil-num=8
en-affil=
kn-affil=Tokyo Medical University Hachioji Medical Center, Tokyo
en-keyword=IL-6
kn-keyword=IL-6
en-keyword=colorectal cancer
kn-keyword=colorectal cancer
en-keyword=lymph node metastasis
kn-keyword=lymph node metastasis
en-keyword=hepatic metastasis
kn-keyword=hepatic metastasis
en-keyword=diagnostic signifi cance
kn-keyword=diagnostic signifi cance
END