JaLCDOI 10.18926/AMO/47015
フルテキストURL 65_5_329.pdf
著者 Matsumoto, Yoshinori| Sada, Ken-ei| Takano, Mariko| Toyota, Noriko| Yamanaka, Ryutaro| Sugiyama, Koichi| Wakabayashi, Hiroshi| Kawabata, Tomoko| Otsuka, Fumio| Makino, Hirofumi|
抄録 It is well known that infection is one of the major causes of morbidity and mortality in rheumatic disease patients treated with high-dose glucocorticoids, especially in the early phase after achievement of disease remission. The aim of this study was to identify the risk factors for infection, with a focus on the dose of glucocorticoids administered, following the achievement of disease remission in rheumatic diseases patients. We retrospectively analyzed the medical records of rheumatic disease patients who had been treated with glucocorticoids. The primary endpoint was the incidence rate of infection during a period from 1 to 2 months after the commencement of treatment. From April 2006 to March 2010, 19 of 92 patients suffered from infection during the observation period. Age≧65 yrs, presence of interstitial pneumonia, diagnosis of systemic vasculitis and serum creatinine level≧2.0mg/dl were found to be univariate predictors for infection. However, only the presence of interstitial pneumonia was an independent risk factor for infection (HR=4.50, 95%CI=1.65 to 14.44) by the Cox proportional hazard model. Even after achievement of clinical remission, careful observation is needed for patients with interstitial pneumonia, more so than for those receiving high-dose glucocorticoids.
キーワード infection rheumatic disease glucocorticoids interstitial pneumonia risk factors
Amo Type Original Article
発行日 2011-10
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 329
終了ページ 334
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 22037270
Web of Sience KeyUT 000296116400007
著者 Takano, Mariko| Otsuka, Fumio| Matsumoto, Yoshinori| Inagaki, Kenichi| Takeda, Masaya| Nakamura, Eri| Tsukamoto, Naoko| Miyoshi, Tomoko| Sada, Ken-ei| Makino, Hirofumi|
発行日 2012-01-02
出版物タイトル Molecular and Cellular Endocrinology
資料タイプ 学術雑誌論文