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ID 14007
Eprint ID
14007
フルテキストURL
Thumnail 105_217.pdf 496 KB
タイトル(別表記)
The effects of MCI-186 for ischemic-reperfusion injury during cardiopulumonary bypass
著者
竹尾 正彦 岡山大学医学部第二外科学教室
抄録
To determine the efficacy of MCI-186, a novel free radical scavenger, in ischemia-reperfusion injury during cardiopulumonary bypass (CPB), the following experimental model was applied. Twenty-one mongrel dogs were subjected to 120 minutes of hypothermic global ischemia by aortic cross clamping with intermittent administration of a cardioplegic solution followed by 60 minutes reperfusion. They were assingend to three groups : group A(n=7), no drug was administerd before reperfusion ; group B(n=7), 1ml/kg of physiological saline was administered by bolus injection through the aortic root just before reprefusion ; group C(n=7), MCI-186 (3mg/ml/kg) dissolved in physiological saline was administered in the same manner as group B. Cardiac function (left ventricular systolic pressure, cardiac output, left ventricular maximum dP/dt) after 60 minutes reperfusion expressed as as percent recovery of pre-ischemic state was superior in group C than in groups A and B. Release of lipidperoxide assayed by the TBA method as the difference between coronary artery and sinus were suppressed in the early phase of reperfusion in group C. Myocardial water content after 60 minutes reperfusion was also less in group C than in group A and B. These findings suggest that administration of MCI-186 before reprefusion after ischemia is effective in protecting the heart from ischemia-reperfusion injury.
キーワード
MCI-186
再灌流障害
free radical
心筋保護
体外循環
発行日
1993-02-27
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
105巻
1-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
217
終了ページ
226
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/105/1-2/105_1-2_217/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
Copyright© 岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma