JaLCDOI 10.18926/AMO/31995
フルテキストURL fulltext.pdf
著者 Takeuchi, Mamoru| Morita, Kiyoshi| Iwasaki, Tatsuo| Toda, Yuichiro| Oe, Katsunori| Taga, Naoyuki| Hirakawa, Masahisa|
抄録 <p>To elucidate the effect of adrenomedullin (AM) on fluid homeostasis under cardiopulmonary bypass (CPB), we investigated the serial changes in plasma AM and other parameters related to fluid homeostasis in 13 children (average age, 28.2 months) with congenital heart disease during cardiac surgery under CPB. Arterial blood and urine samples were collected just after initiation of anesthesia, just before commencement of CPB, 10 min before the end of CPB, 60 min after CPB, and 24 h after operation. Plasma AM levels increased significantly 10 min before the end of CPB and decreased 24 h after operation. Urine volume increased transiently during CPB, which paralleled changes in AM. Simple regression analysis showed that plasma AM level correlated significantly with urinary vasopressin, urine volume, urinary sodium excretion, and plasma osmolarity. Stepwise regression analysis indicated that urine volume was the most significant determinant of plasma AM levels. Percent rise in AM during CPB relative to control period correlated with that of plasma brain natriuretic peptide (r = 0.57, P &#60; 0.01). Our results suggest that AM plays an important role in fluid homeostasis under CPB in cooperation with other hormones involved in fluid homeostasis.</p>
キーワード adrenomedullin cardiopulmonary bypass vasopressin pediatric cardiac surgery brain natriuretic peptide
Amo Type Article
発行日 2001-08
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 245
終了ページ 252
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 11512567
Web of Science KeyUT 000170367200007