JaLCDOI 10.18926/AMO/41324
フルテキストURL 64_6_385.pdf
著者 Miyatake, Nobuyuki| Moriyasu, Hideyuki| Sakano, Noriko| Tada, Shinya| Suzue, Takeshi| Hirao, Tomohiro|
抄録 The link between changes in estimated glomerular filtration rate (eGFR) and cigarette smoking was evaluated in Japanese male workers with a 5-year follow-up. We examined the data of 456 Japanese male workers, aged 22-70 years, who were taking no medications, and from this group, 286 men (43.5±8.2 years) were followed for 5-years. Habits of cigarette smoking were obtained during interviews by well-trained staff. The influence of cigarette smoking on eGFR was evaluated. In the first analysis, there was no significant difference in eGFR between subjects with and without cigarette smoking. In the second analysis, eGFR was significantly reduced after 5 years in all subjects. Changes in eGFR in subjects with cigarette smoking (-1.90±12.31ml/min/1.73m2) were significantly smaller than those in subjects without cigarette smoking (-4.97±12.05ml/min/1.73m2). At follow-up, we found that eGFR was weakly and negatively correlated with the number of cigarettes smoked (/day). The present study indicated that cigarette smoking may be an important modifiable factor for eGFR in Japanese male workers who are not taking any medications.
キーワード cigarette smoking estimated glomerular filtration rate (eGFR) male worker
Amo Type Original Article
発行日 2010-12
出版物タイトル Acta Medica Okayama
64巻
6号
出版者 Okayama University Medical School
開始ページ 385
終了ページ 390
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 21173808
Web of Sience KeyUT 000285664200005
JaLCDOI 10.18926/AMO/32012
フルテキストURL fulltext.pdf
著者 Ohke, Masashi| Tada, Shinya| Kataoka, Mikiko| Matsuo, Kiyoshi| Nabe, Makoto| Harada, Mine|
抄録 <p>This study investigated the relation between asthma attacks and levels of plasma fibronectin (FN) and serum eosinophilic cationic protein (ECP) in patients with bronchial asthma in order to clarify the role of FN in the airway inflammation of bronchial asthma. Plasma levels of FN were significantly higher (P &#60; 0.025) in patients with bronchial asthma than in healthy controls. They were also significantly higher (P &#60; 0.05) in non-atopic asthmatics than in atopic asthmatics. Furthermore, plasma FN was lower during the attack than the non-attack stage (P &#60; 0.025), and a significant increase of plasma FN was noted (P &#60; 0.05) in asthmatics who had more severe and more frequent attacks. Serum levels of ECP were significantly higher during the attack than the non-attack stage (P &#60; 0.005). An increase of plasma FN in the non-attack stage after attacks showed a significant correlation (P &#60; 0.05) with a decrease of serum ECP. These observations clearly indicate that the decrease in plasma FN associated with attacks is closely related to aggravation of airway inflammation, and that the increase in plasma FN in the non-attack stage reflects chronic airway inflammation. These results suggest that the fluctuation in plasma levels of FN may be one of the factors affecting allergic inflammation and attacks in bronchial asthma.</p>
キーワード adhesion molecule asthma attck bronchial asthma eosinophil cationic protein fibronectin
Amo Type Article
発行日 2001-04
出版物タイトル Acta Medica Okayama
55巻
2号
出版者 Okayama University Medical School
開始ページ 91
終了ページ 96
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 11332204
Web of Sience KeyUT 000168195700005
JaLCDOI 10.18926/AMO/32009
フルテキストURL fulltext.pdf
著者 Ohke, Masashi| Tada, Shinya| Nabe, Makoto| Matsuo, Kiyoshi| Kataoka, Mikio| Harada, Mine|
抄録 <p>Allergic and chronic inflammation of the airway is regarded as the main pathogenesis of bronchial asthma, in which adhesion of inflammatory cells requires the expression of adhesion molecules. Thus, to clarify the role of fibronectin (FN) in the airway inflammation of bronchial asthma, FN levels in plasma and bronchoalveolar lavage fluid (BALF) from bronchial asthmatics were determined. FN concentrations in plasma and BALF were measured by enzyme-linked immunosorvent assay (ELISA) in 17 asthmatic patients and 10 healthy controls to elucidate the role of FN in allergic inflammation. The mean FN/albumin (Alb) level in the BALF of asthmatic patients was 2.973 micrograms/mg, which was significantly higher than that of healthy controls (0.727 microgram/mg). Non-atopic asthmatics showed a significantly higher level of FN in their BALF in comparison with atopic asthmatics, although the ratio of FN to albumin showed no significant difference. FN levels in BALF correlated significantly with total cell density (r = 0.71, P &#60; 0.05) and alveolar macrophage density (r = 0.64, P &#60; 0.05). FN levels in plasma did not correlate with those in BALF. In conclusion, increased FN in BALF, which was produced locally in the airways of asthmatic patients, is actively involved in the regulation of allergic inflammation.</p>
キーワード airway inflammation adhesion molecule bronchoalveolar lavage fluid bronchial asthma fibronectin
Amo Type Article
発行日 2001-04
出版物タイトル Acta Medica Okayama
55巻
2号
出版者 Okayama University Medical School
開始ページ 83
終了ページ 89
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 11332203
Web of Sience KeyUT 000168195700004
JaLCDOI 10.18926/AMO/31991
フルテキストURL fulltext.pdf
著者 Takehara, Hideki| Tada, Shinya| Kataoka, Mikio| Matsuo, Kiyoshi| Ueno, Yoshiki| Ozaki, Shinji| Miyake, Toshitsugu| Fujimori, Yoshiaki| Yamadori, Ichiro| Harada, Mine|
Amo Type Article
発行日 2001-08
出版物タイトル Acta Medica Okayama
55巻
4号
出版者 Okayama University Medical School
開始ページ 205
終了ページ 211
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
Web of Sience KeyUT 000170367200002
JaLCDOI 10.18926/AMO/31916
フルテキストURL fulltext.pdf
著者 Kimura, Ikuro| Tsubota, Teruhiko| Tada, Shinya| Sogawa, Jujiro|
抄録 <p>The presence of antibodies against adult T cell leukemia antigen (ATLA) was studied in 59 patients with chronic respiratory diseases. Of 13 patients with diffuse panbronchiolitis, 3, who developed adult T cell leukemia, had the anti-ATLA antibody and 8 had the related, anti-ATLA-like antibody. Of 13 cases of idiopathic interstitial pneumonia, 8 had the anti-ATLA-like antibody. Except for only one case, these antibodies were not detected in 33 patients with bronchial asthma or sarcoidosis and 20 healthy adults examined. These results suggested that the test of these antibodies would be useful for the diagnosis of diffuse panbronchiolitis and idiopathic interstitial pneumonia which frequently develop lung cancers.</p>
キーワード anti-ATLA antibody ATLA-related antibodies diffuse panbronchiolitis idiopathic interstitial pueumonia adult T cell leukemia
Amo Type Article
発行日 1986-12
出版物タイトル Acta Medica Okayama
40巻
6号
出版者 Okayama University Medical School
開始ページ 281
終了ページ 284
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 3493619
Web of Sience KeyUT A1986F275800001
JaLCDOI 10.18926/AMO/31574
フルテキストURL fulltext.pdf
著者 Shinagawa, Katsuji| Imajo, Kenji| Tada, Shinya| Tsubota, Teruhiko| Kimura, Ikuro|
抄録 The activity of pulmonary lymphocytes was evaluated by the detection of interleukin-2 (IL-2) receptor alpha mRNA expression in lung cancer patients associated with diffuse interstitial shadow on roentgenograms of their lungs. Reverse transcription coupled with the polymerase chain reaction was used to detect mRNA expression. In 5 of 6 patients, IL-2R alpha mRNA expression was increased in pulmonary lymphocytes compared with 4 normal controls. The expression in this mRNA in peripheral blood lymphocytes was almost undetectable in either normal controls or these patients. These results suggest that pulmonary lymphocytes in patients with lung cancer associated with diffuse interstitial shadows are activated and may promote the inflammatory process generating pulmonary fibrosis.
キーワード pulmonary fibrosis lung cancer pulmonary lymphocytes IL-2R α mRNA RT-PCR
Amo Type Article
発行日 1993-04
出版物タイトル Acta Medica Okayama
47巻
2号
出版者 Okayama University Medical School
開始ページ 73
終了ページ 78
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 Copyright© 1999 Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 8506752
Web of Sience KeyUT A1993LA45200001
関連URL http://ousar.lib.okayama-u.ac.jp/metadata/5957
JaLCDOI 10.18926/AMO/31564
フルテキストURL fulltext.pdf
著者 Imajo, Kenji| Shinagawa, Katsuji| Tada, Shinya| Tsubota, Teruhiko| Kimura, Ikuro|
抄録 <p>Newly designed oligonucleotide primers, KI-7 and KI-8 for the human T cell lymphotropic virus type I (HTLV-I) pX gene were synthesized using an automated DNA synthesizer. Previously known HTLV-I-infected cell lines, MT-1 and MT-2, were used as positive controls and HTLV-I-uninfected cell lines, Molt-4, SBC-3, ABC-1, and EBC-1, as negative controls. Peripheral blood mononuclear cells from 17 patients with anti-HTLV-I antibody and 10 healthy individuals without anti-HTLV-I antibody were studied by polymerase chain reaction (PCR) with KI-7 and KI-8. All DNA samples from HTLV-I-infected cell lines and 17 patients with anti-HTLV-I antibodies showed positive signals of the HTLV-I pX gene. None of the DNA samples from HTLV-I-uninfected cell lines or 10 healthy individuals showed positive signals. When serially diluted DNA of MT-2 cells were amplified by 35 cycles of PCR, the detection limit of the pX gene by using the primer pairs was DNA from about 1.5 MT-2 cells. Specificity and detectable capacity of primer pairs, KI-7 and KI-8 were confirmed to be enough to use for the diagnosis of HTLV-I infection.</p>
キーワード HTLV-1 polymerase chain reaction oligonucleotide primer DNA synthesis
Amo Type Article
発行日 1993-12
出版物タイトル Acta Medica Okayama
47巻
6号
出版者 Okayama University Medical School
開始ページ 355
終了ページ 361
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 8128908
Web of Sience KeyUT A1993MP00700001
JaLCDOI 10.18926/AMO/31560
フルテキストURL fulltext.pdf
著者 Imajo, Kenji| Shinagawa, Katsuji| Tada, Shinya| Tsubota, Teruhiko| Kimura, Ikuro|
抄録 <p>The presence of the HTLV-I gene in peripheral blood mononuclear cells was studied by polymerase chain reaction in 42 patients including 16 with lung cancer, 12 with diffuse panbronchiolitis (DPB), 11 with idiopathic interstitial pneumonia (IIP), and 3 with pneumoconiosis and hematological malignancy. Sequences equal to a part of the pX gene were found in 44% of the lung cancer cases, 50% of the DPB cases, 55% of the IIP cases, and 100% of the cases of pneumoconiosis and leukemia. In the lung cancer cases, detection of the pX gene was frequently associated with the existence of diffuse interstitial pulmonary shadows. The pX gene was detected in 100% of patients with anti-HTLV-I antibody, 50% of patients with HTLV-I-related reaction and 14% of patients who tested seronegative. It may be inferred from the results that respiratory diseases that produce diffuse interstitial pulmonary shadows are closely associated with HTLV-I infection and that the HTLV-I-related reaction to the immunofluorescent test might reflect the latent infection state of HTLV-I.</p>
キーワード HTLV-1 polymerase chain reaction HTLV-I associated bronchiolo-alveolar disorder HTLV-I associated lung cancer immunofluorescent assay
Amo Type Article
発行日 1993-12
出版物タイトル Acta Medica Okayama
47巻
6号
出版者 Okayama University Medical School
開始ページ 363
終了ページ 368
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 8128909
Web of Sience KeyUT A1993MP00700002
JaLCDOI 10.18926/AMO/31532
フルテキストURL fulltext.pdf
著者 Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Morinaga, Hiroshi| Kitani, Hikaru| Nakagawa, Saburo| Matsuoka, Takashi| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
抄録 <p>Candida albicans-induced histamine release from basophils was studied in 54 patients with bronchial asthma in comparison with the release caused by house dust and anti-IgE. The release of histamine induced by C. albicans and that induced by house dust were closely related to the serum levels of specific IgE antibodies as expressed by RAST scores. A correlation of C. albicans-induced histamine release with the release caused by anti-IgE was not generally observed. On the other hand, a close correlation was found between house dust- and anti-IgE-induced histamine release. It was suggested from these results that the differences between C. albicans- and house dust-induced histamine release might be due to the different antigenicity of the two allergens.</p>
キーワード histamine release C. albicans house dust anti-IgE antigeniciy
Amo Type Article
発行日 1985-06
出版物タイトル Acta Medica Okayama
39巻
3号
出版者 Okayama University Medical School
開始ページ 191
終了ページ 197
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 2411109
Web of Sience KeyUT A1985ALG3300004
著者 Arimori, Shigeru| Tada, Shinya| Nakata, Yasunari| Kobashi, Hidehiro| Ichikawa, Yukinobu| Koriyama, Kenji|
発行日 1975-12
出版物タイトル Acta Medica Okayama
29巻
6号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/30510
フルテキストURL fulltext.pdf
著者 Matsuo, Kiyoshi| Tada, Shinya| Shibayama, Takuo| Ueno, Yoshiki| Miyake, Toshitugu| Takehara, Hideki| Kataoka, Mikio| Harada, Mine| Kimura, Ikuro|
抄録 <p>&#60;P&#62;Idiopathic interstitial pneumonia (IIP) is a progressive and often fatal pulmonary disorder, and evaluating the prognosis of patients with IIP has never been sufficient. Accordingly, factors including clinical features, laboratory data, cellular components in bronchoalveolar lavage (BAL) fluid and response to corticosteroid therapy were analyzed in 35 patients with IIP whose median age of respiratory onset was 60 years (range; 37-77 years). Nineteen patients (54.3%) were in the active stage of IIP and 16 of them were treated with corticosteroids. Significant prognostic factors were the neutrophil percentage in BAL fluid, interstitial shadows on chest radiograph, pulmonary function, blood oxygen level, grade of dyspnea, and disease activity at the initial examination. Patients in the active stage showed higher proportions of neutrophils and eosinophils in BAL fluid than those in the non-active stage. Despite corticosteroid therapy, the survival of patients in the active stage was significantly shorter than those in the non-active stage. Fifty percent of the patients treated with corticosteroids were regarded as responders at 1 month after the initiation of therapy; however, there was no significant difference between responders and non-responders in terms of survival time. In conclusion, disease activity and neutrophils in BAL fluid may be important predictors of the prognosis of IIP.&#60;/P&#62;</p>
キーワード idiopathic interstitial pneumonia (LLP) prognostic factor corticosteroid therapy bronchoalveolar lavage(BAL) disease activity
Amo Type Article
発行日 1996-02
出版物タイトル Acta Medica Okayama
50巻
1号
出版者 Okayama University Medical School
開始ページ 37
終了ページ 46
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 8701780
Web of Sience KeyUT A1996TY06000006
JaLCDOI 10.18926/AMO/30359
フルテキストURL fulltext.pdf
著者 Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Morinaga, Hiroshi| Kitani, Hikaru| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
抄録 <p>Anti-IgE-induced histamine release from basophils was examined in 46 asthmatic subjects using a whole blood method. Basophils from subjects less than 30 years old released more histamine than those from subjects aged 41 to 50. The age at onset of the disease also affected the reactivity of basophils to anti-IgE: basophils showed a high response in subjects whose age at onset was between 0 and 10 years, and low response in the subjects whose age at onset was between 41 and 50 years. There was a correlation between histamine release and serum IgE levels. However, individual dose-response curves of histamine release varied greatly in whom serum IgE levels were low.</p>
キーワード histamine release whole blood patient age age a? onset serum IgE levels
Amo Type Article
発行日 1984-06
出版物タイトル Acta Medica Okayama
38巻
3号
出版者 Okayama University Medical School
開始ページ 275
終了ページ 280
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6205544
Web of Sience KeyUT A1984SY25800008
JaLCDOI 10.18926/AMO/30339
フルテキストURL fulltext.pdf
著者 Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Morinaga, Hiroshi| Shiota, Yutaro| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
抄録 <p>Seventy-one cases of bronchial asthma were classified into three types: bronchospasm, bronchospasm-hypersecretion and bronchiolar obstruction types. The characteristics of each type were studied in relation to patient age and age at onset of the disease. In the 71 subjects studied, the most frequent type was the bronchospasm type followed by the bronchospasm-hypersecretion type and bronchiolar obstruction type. Intractable asthma was most frequently observed in the bronchiolar obstruction type and least in the bronchospasm type. Most of the patients under 50 years of age showed the bronchospasm type. The bronchospasm-hypersecretion type was characteristically accompanied by blood eosinophilia when the patient age was under 50 years. In the bronchospasm-hypersecretion type, the incidence of intractable asthma was high in patients under 50 years of age, but not remarkable in those over 50. A large proportion of the patients over 50 years of age were of the bronchiolar obstruction type. There was no difference in the incidence of intractable asthma between the two groups classified by age at onset.</p>
キーワード asthma classification clinical symptoms patient age age at onset
Amo Type Article
発行日 1984-10
出版物タイトル Acta Medica Okayama
38巻
5号
出版者 Okayama University Medical School
開始ページ 471
終了ページ 477
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6083702
Web of Sience KeyUT A1984TQ61100007
JaLCDOI 10.18926/AMO/30325
フルテキストURL fulltext.pdf
著者 Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Morinaga, Hiroshi| Kitani, Hikaru| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
抄録 <p>The correlation between blood eosinophilia and anti-IgE-mediated histamine release was investigated in 22 bronchial asthma patients with peripheral eosinophilia (over 8%). In the cases (Group A-1 and Group A-2) in which house dust was the specific antigen, significant histamine release from basophils was induced by anti-IgE and house dust. The result indicates a relationship between eosinophilia and the IgE-mediated mechanism of disease onset. In the cases (Group A-3) with RAST scores of 0+ and 1+ to house dust, the anti-IgE-induced histamine release varied from low to high percentages, and the participation of the IgE-mediated pathway was indicated in some cases. In the cases (Group B) with negative skin reactions, few patients had a family history of allergic disease. Their ages at onset were higher, and they demonstrated lower total IgE levels. These cases showed an extremely low percent of histamine release from basophils, which indicated the absence of a correlation between eosinophilia and IgE-mediated mechanisms.</p>
キーワード blood eosinophilia histamine release IgE-mediated reaction asthma
Amo Type Article
発行日 1984-12
出版物タイトル Acta Medica Okayama
38巻
6号
出版者 Okayama University Medical School
開始ページ 525
終了ページ 531
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6084401
Web of Sience KeyUT A1984TX98000005