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ID 50632
フルテキストURL
著者
Motose, Hiroyasu Division of Biological Sciences; Graduate School of Natural Science and Technology; Okayama University
Takatani, Shogo Division of Biological Sciences; Graduate School of Natural Science and Technology; Okayama University
Ikeda, Tatsuya Division of Biological Sciences; Graduate School of Natural Science and Technology; Okayama University
Takahashi, Taku Division of Biological Sciences; Graduate School of Natural Science and Technology; Okayama University
抄録
NIMA-related kinase 6 (NEK6) regulates cellular expansion and morphogenesis through microtubule organizaiton in Arabidopsis thaliana. Loss-of-function mutations in NEK6 (nek6/ibo1) cause ectopic outgrowth and microtubule disorganization in epidermal cells. We recently found that NEK6 forms homodimers and heterodimers with NEK4 and NEK5 to destabilize cortical microtubules possibly by direct binding to microtubules and the β-tubulin phosphorylation. Here, we identified a new allele of NEK6 and further analyzed the morphological phenotypes of nek6/ibo1 mutants, along with alleles of nek4 and nek5 mutants. Phenotypic analysis demonstrated that NEK6 is required for the directional growth of roots and hypocotyls, petiole elongation, cell file formation, and trichome morphogenesis. In addition, nek4, nek5, and nek6/ibo1 mutants were hypersensitive to microtubule inhibitors such as propyzamide and taxol. These results suggest that plant NEKs function in directional cell growth and organ development through the regulation of microtubule organization.
キーワード
Arabidopsis
NIMA-related kinase
directional growth
epidermis
microtubule
tubulin
発行日
2012-12
出版物タイトル
Plant Signaling & Behavior
7巻
12号
開始ページ
1552
終了ページ
1555
ISSN
1559-2316
資料タイプ
学術雑誌論文
言語
English
著作権者
© 2012 Landes Bioscience
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