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ID 31008
JaLCDOI
フルテキストURL
著者
Saito, Daiji Okayama University
Ueeda, Masayuki Okayama University
Hina, Kazuyoshi Okayama University
Watanabe, Hirofumi Okayama University
Mima, Tsutomu Okayama University
Hasui, Masahiro Okayama University
Yamada, Nobuyuki Okayama University
Haraoka, Shoichi Okayama University
Tsuji, Takao Okayama University
抄録

The effect of the heart rate and myocardial contractile force on the extravascular resistance to blood flow of the left anterior descending coronary artery (LAD) was evaluated in 15 mongrel dogs anesthetized with sodium pentobarbital. The LAD was maximally dilated by intracoronary infusion of adenosine, which precluded the influence of vasomotor tone. Increases in the heart rate and myocardial contractile force decreased coronary blood flow in the absence of a change in coronary perfusion pressure. The changes in mean coronary resistance showed a significant linear relationship to changes in developed tension. The changes in coronary resistance caused by varying the heart rate and contractile force were so small that a normal coronary vascular tree could easily compensate for the increase in resistance. However, it is supposed that with critical stenosis of the vascular tree even a small increase in resistance might cause deleterious effects on coronary blood flow.

キーワード
contractile force
tachycardia
extravascular resistance
coronary flow
adenosine
Amo Type
Article
発行日
1988-12
出版物タイトル
Acta Medica Okayama
42巻
6号
出版者
Okayama University Medical School
開始ページ
335
終了ページ
342
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT