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ID 52907
フルテキストURL
著者
Oshima, Masamitsu Tokyo Univ Sci, Res Inst Sci & Technol
Inoue, Kaoru Tokyo Univ Sci, Grad Sch Ind Sci & Technol, Dept Biol Sci & Technol
Nakajima, Kei Tokyo Univ Sci, Grad Sch Ind Sci & Technol, Dept Biol Sci & Technol
Tachikawa, Tetsuhiko Showa Univ, Sch Dent, Dept Oral Pathol
Yamazaki, Hiromichi Tokyo Univ Sci, Grad Sch Ind Sci & Technol, Dept Biol Sci & Technol
Isobe, Tomohide Showa Univ, Sch Dent, Dept Oral Pathol
Sugawara, Ayaka Tokyo Univ Sci, Grad Sch Ind Sci & Technol, Dept Biol Sci & Technol
Ogawa, Miho Tokyo Univ Sci, Res Inst Sci & Technol
Tanaka, Chie Tokyo Univ Sci, Grad Sch Ind Sci & Technol, Dept Biol Sci & Technol
Saito, Masahiro Tokyo Univ Sci, Grad Sch Ind Sci & Technol, Dept Biol Sci & Technol
Kasugai, Shohei Tokyo Med & Dent Univ, Grad Sch, Sect Oral Implantol & Regenerat Dent Med
Takano-Yamamoto, Teruko Tohoku Univ, Grad Sch Dent, Div Orthodont & Dentofacial Orthoped
Inoue, Takashi Tokyo Dent Coll, Dept Clin Pathophysiol
Tezuka, Katsunari Tokyo Univ Sci, Res Inst Sci & Technol
Kuboki, Takuo Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Oral Rehabil & Regenerat Med
Yamaguchi, Akira Tokyo Med & Dent Univ, Grad Sch, Dept Oral Restitut, Sect Oral Pathol
Tsuji, Takashi Tokyo Univ Sci, Res Inst Sci & Technol
抄録
Bio-hybrid artificial organs are an attractive concept to restore organ function through precise biological cooperation with surrounding tissues in vivo. However, in bio-hybrid artificial organs, an artificial organ with fibrous connective tissues, including muscles, tendons and ligaments, has not been developed. Here, we have enveloped with embryonic dental follicle tissue around a HA-coated dental implant, and transplanted into the lower first molar region of a murine tooth-loss model. We successfully developed a novel fibrous connected tooth implant using a HA-coated dental implant and dental follicle stem cells as a bio-hybrid organ. This bio-hybrid implant restored physiological functions, including bone remodelling, regeneration of severe bone-defect and responsiveness to noxious stimuli, through regeneration with periodontal tissues, such as periodontal ligament and cementum. Thus, this study represents the potential for a next-generation bio-hybrid implant for tooth loss as a future bio-hybrid artificial organ replacement therapy.
発行日
2014-08-13
出版物タイトル
Scientific Reports
4巻
ISSN
2045-2322
資料タイプ
学術雑誌論文
言語
English
著作権者
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
論文のバージョン
publisher
査読
有り
DOI
Web of Sience KeyUT