JaLCDOI 10.18926/AMO/32818
フルテキストURL fulltext.pdf
著者 Ishikawa, Takaki| Tachibana, Toshiaki| Ishikawa, Hiroshi| Miyaishi, Satoru| Ishizu, Hideo|
抄録 <p>Healthy subjects 40 years old were used as controls in a study of stellate cells (S-100 protein-containing cells, or S-100 cells) in subjects with chronic alcoholism and fatty liver or fatty cirrhosis. S-100 cells were sparsely found in the adenohypophysis of control subjects, and these cells sometimes formed small clusters. However, in chronic alcoholics with fatty liver or fatty cirrhosis, the number of stellate cells in the anterior pituitary tended to be 17 times higher than it was in the control group. No increase in the number of S-100 positive cells that constitute the large and small follicles in the intermediate pituitary. The physiological function of the S-100 protein has not yet been identified. The fact that an increase in prolactin-secreting and growth hormone-secreting cells, as well as a decrease in gonadotrophs were observed in the hypophysis of alcoholics suggests that the function of stellate cells may be closely related to these phenomena. Our results also imply that the stellate cells found in the anterior and intermediate pituitary differ in function although they both produce S-100 proteins.</p>
キーワード S-100 protein pituitary alcoholism
Amo Type Article
発行日 2003-04
出版物タイトル Acta Medica Okayama
57巻
2号
出版者 Okayama University Medical School
開始ページ 53
終了ページ 58
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 12866744
Web of Sience KeyUT 000182520400002
JaLCDOI 10.18926/AMO/32816
フルテキストURL fulltext.pdf
著者 Ishikawa, Takaki| Miyaishi, Satoru| Tachibana, Toshiaki| Yamamoto, Yuji| Ishizu, Hideo|
抄録 <p>In this study we used paraffin-embedded human pituitary obtained from 248 autopsy cases and identified mixed cell follicles by the immunohistochemical method. We examined the number and size of the mixed cell follicles, and the ratio of each component cell of these follicles, in the anterior pituitary at various age groups. The number of follicles increased with age, and the size of the follicles also tended to enlarge with age. Statistical analysis showed that a high correlation existed between age and the number or the size of the mixed cell-follicles formed by various adenohypophyseal cells. In addition, when the proportions of the different cell types that formed the follicles were examined, sex differences were observed with aging for the GH cells, the PRL cells, and the gonadotroph (GTH) cells, while no changes were observed with aging in both men and women for the ACTH cells and TSH cells. These results indicate that the number, size, and ratio of each component cell of follicles in the anterior pituitary are adequately applicable for the purpose of age estimation in routine forensic medicine.</p>
キーワード mixed cell-follicle human anterior pituitary age estimation
Amo Type Article
発行日 2003-04
出版物タイトル Acta Medica Okayama
57巻
2号
出版者 Okayama University Medical School
開始ページ 83
終了ページ 89
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 12866748
Web of Sience KeyUT 000182520400006