start-ver=1.4 cd-journal=joma no-vol=36 cd-vols= no-issue=4 article-no= start-page=253 end-page=261 dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=198208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Specific suppression of the local GVH reaction by F1 spleen cells. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The local graft-versus-host (GvH) reaction in (C57BL/6 X BALB/c) F1 hybrid mice, assayed by popliteal lymph node enlargement, was specifically depressed by an injection of parental lymphocytes mixed with spleen cells from F1 mice pretreated with the same parental lymphocytes. Suppressor activity of CBF1 spleen cells was obtained 7 days after inoculation of parental lymphocytes, and peaked on day 10. The suppressive activity was induced by only spleen cells from CBF1 which was inoculated Balb/c lymphocytes, but not C57BL/6 lymphocytes. The lymphocyte subpopulation responsible for the suppressive activity was noticed in T cell population.

en-copyright= kn-copyright= en-aut-name=TagashiraYoshiaki en-aut-sei=Tagashira en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Okayama University en-keyword=graft-vresus-host reaction kn-keyword=graft-vresus-host reaction en-keyword=suppressor cells kn-keyword=suppressor cells en-keyword=CBF1 kn-keyword=CBF1 en-keyword=BALB/C kn-keyword=BALB/C END