Okayama University Medical School Acta Medica Okayama 0386-300X 36 4 1982 Specific suppression of the local GVH reaction by F1 spleen cells. 253 261 EN Yoshiaki Tagashira Article 10.18926/AMO/30656 <p>The local graft-versus-host (GvH) reaction in (C57BL/6 X BALB/c) F1 hybrid mice, assayed by popliteal lymph node enlargement, was specifically depressed by an injection of parental lymphocytes mixed with spleen cells from F1 mice pretreated with the same parental lymphocytes. Suppressor activity of CBF1 spleen cells was obtained 7 days after inoculation of parental lymphocytes, and peaked on day 10. The suppressive activity was induced by only spleen cells from CBF1 which was inoculated Balb/c lymphocytes, but not C57BL/6 lymphocytes. The lymphocyte subpopulation responsible for the suppressive activity was noticed in T cell population.</p> No potential conflict of interest relevant to this article was reported.