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ID 32608
フルテキストURL
著者
Seno, Satimaru Okayama University
Miyahara, Masanobu Okayama University
Ochi, Osamu Okayama University
Matsuoka, Kenichi Okayama University
Toyama, Yuki Okayama University
Shibata, Takashi Okayama University
抄録

As has been well established, reticulocytes (RC) synthesize the species specific protein, globin, actively for about 24 hours or more till the time of their complete maturation1,2,3. This will be possible only in the presence of messenger RNA (m-RNA)4,5. Since the splendid hypothesis of m-RNA proposed by JACOB and MONOD6 for explaining the mechanism of the transfer of genetic information from nucleus to cytoplasm, it has largely been accepted through the numerous observations that followed7,8,9,10. However, the m-RNA hypothesis, which has been deduced by observing the protein synthesis in E. Coli, includes the meaning of labile RNA which is incessantly decomposed and newly synthesized to compensate the rapid degradation. As m-RNA cannot be synthesized in RC which have no detectable DNA, it has been supposed that the m-RNA of RC should be considerably stablell,12,13. Even in the denucleated cells, however, the RNA synthesis might be possible because Borsook reported the positive RNA synthesis of RC14, and this result has recently been reconfirmed by BURNY15.

発行日
1963
出版物タイトル
Acta Medicinae Okayama
17巻
5号
出版者
Okayama University Medical School
NCID
AA00041342
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Amo Type
Brief Note
Submission Path
amo/vol17/iss5/5