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ID 13983
Eprint ID
13983
フルテキストURL
Thumnail 105_127.pdf 1.6 MB
タイトル(別表記)
Studies on anti-HTLV-Ⅰ antibody in interstitial lung diseases Part 2. Anti-HTLV-ⅠIgG, IgM, and IgA antibodies in HTLV-Ⅰ associated bronchiolo-alveolar disorder (HABA)
著者
植野 克巳 岡山大学医学部第二内科学教室
抄録
To study the pathogenesis of HTLV-Ⅰassociated bronchiolo-alveolar disorder (HABA), Western blot analysis was performed using MT-2 cell lysate antigens on the serum of 6 patients with HABA, 7 patients with adult T cell leukamia (ATL), 14 asymptomatic carriers and 9 healthy controls. Five(83%) of the 6 HABA patients were positive for anti-HTLV-Ⅰ IgA antibodies, although all 7 ATL patients and 11 of the 14 asymptomatic carriers were negative. All HABA and ATL patients and asymptomatic carriers were positive for anti-HTLV-Ⅰ IgG antibodies. Four(67%) of the 6 HABA patients, 2(29%) of the 7 ATL patients and 9(64%) of the 14 asymptomatic carriers were positive for anti-HTLV-Ⅰ IgM antibodies. Statistically there was little difference in the incidences of anti-HTLV-Ⅰ IgG and IgM antibodies among HABA and ATL patients and asymptomatic carriers, but the HABA patients showed a significantly higher incedence of IgA antibody than the ATL patients and asymptomatic carriers. Since specific IgA antibodies are produced in the local infected mucosa and part of the IgA antibodies are transferred into the serum, in conclusion, the anti-HTLV-Ⅰ IgA antibodies in HABA patients reflect the localization of HTLV-Ⅰ in lungs which play an important role in the pathogenesis of HABA.
キーワード
HTLV-Ⅰ関連細気管支・肺胞異常症
抗 HTLV-ⅠIgA 抗体
発行日
1993-02-27
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
105巻
1-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
127
終了ページ
134
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/105/1-2/105_1-2_127/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma