JaLCDOI 10.18926/AMO/32273
フルテキストURL fulltext.pdf
著者 Ucar, Peyman| Gocmen, Cemil| Secilmis, Ata| Karatas, Yusuf| Singirik, Ergin| Onder, Serpil| Dikmen, Atilla| Baysal, Firuz|
抄録 <p>The applications of ultraviolet (UV) light (336 nm) on the upper oesophageal strips of frog elicited relaxant responses in the presence of NaNO2 (50 microM). The tissues were mounted under the tension 0.5 g in an organ bath containing Ringer solution, maintained at 25 degrees C and gassed with 100% O2. The responses were recorded on a kymograph via an isotonic lever. Antimegaloblastic agents, including hydroxocobalamin (1, 10, and 100 microM), cyanocobalamin (1, 10, 25, and 100 microM), and folic acid (1, 10, 50, 100, and 200 microM), significantly attenuated the relaxation response to UV light. Folinic acid (1, 10, 25, and 100 microM), however, enhanced the relaxation. Pyrogallol (50 microM), hydroquinone (50 microM), and diethyldithiocarbamic acid (8 mM) were found ineffective for attenuation, though FeSO4 (200, 400, and 500 microM) and hemoglobin (50 microM), respectively, exerted significant inhibition. L-arginine methylester (500 microM) did not impair UV-induced relaxation. Based on these results, we concluded that a mechanism involving undefined action(s) of antimegaloblastic drugs may cause alterations in the UV light-induced relaxation of the tissue used.</p>
キーワード ultraviolet light frog oesophageal strip hydroxocobalamin cyanocobalamin folic acid
Amo Type Article
発行日 2000-08
出版物タイトル Acta Medica Okayama
54巻
4号
出版者 Okayama University Medical School
開始ページ 147
終了ページ 152
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 10985174
Web of Sience KeyUT 000089132800002