JaLCDOI 10.18926/AMO/32845
フルテキストURL fulltext.pdf
著者 Niimi, Takashi| Yoshinouchi, Takeo| Ohtsuki, Yuji| Fujita, Jiro| Sato, Shigeki| Sugiura, Yoshiki| Ohta, Kazutaka| Kajiura, Motoharu| Ueda, Ryuzo|
抄録 <p>Nonspecific interstitial pneumonia (NSIP) has been recognized as a separate histological classification of interstitial lung disease. Similar features are found not only in idiopathic NSIP, but also in NSIP associated with collagen vascular disorder (CVD-NSIP). We examined the clinical symptoms, laboratory findings, and prognosis of 13 cases of idiopathic NSIP and 11 cases of CVD-NSIP. Immunohistochemical staining was performed using the streptavidin/biotin/peroxidase method with anti-alpha-smooth muscle actin antibody. No differences in the distribution of clinical features, laboratory findings, and prognosis were observed between idiopathic NSIP and CVD-NSIP. In immunohistochemical staining of the fibrosing areas, myofibroblasts were observed in 7 of 13 idiopathic NSIP cases, but in 10 of 11 CVD-NSIP cases. With regards to intra-alveolar organization, myofibroblasts were observed in all 10 CVD-NSIP cases, but they were observed in only 2 of 9 idiopathic NSIP cases. We found a significantly higher myofibroblast proliferation in the intra-alveolar organization of CVD-NSIP compared to idiopathic NSIP. Clinically, idiopathic NSIP and CVD-NSIP are similar, but are pathologically different.</p>
キーワード interstitial pneumonia nonspecific interstitial pneumonia myofibroblast collagen vascular disorder
Amo Type Article
発行日 2003-02
出版物タイトル Acta Medica Okayama
57巻
1号
出版者 Okayama University Medical School
開始ページ 33
終了ページ 38
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 12765222
Web of Science KeyUT 000181198200005
JaLCDOI 10.18926/AMO/31702
フルテキストURL fulltext.pdf
著者 Yoshinouchi, Takeo| Ohtsuki, Yuji| Fujita, Jiro| Sugiura, Yoshiki| Banno, Shogo| Sato, Shigeki| Ueda, Ryuzo|
抄録 <p>Pathologic features of Mycoplasma pneumoniae infection (M. pneumonia) are generally non-specific, and the literature regarding the pathologic features of M. pneumonia with intraalveolar exudates is limited. Clinical and histopathological studies were performed in 3 patients with M. pneumonia which did not respond to erythromycin and minocycline, but all rapidly recovered after corticosteroid therapy. In pathologic findings, we observed intraalveolar exudates and focal organization in M. pneumonia, and its intraalveolar lesions were compared between M. pneumonia and bronchiolitis obliterans organizing pneumonia containing fibrin (BOOP). Immunohistochemical studies were performed using the streptavidin biotin peroxidase complex method with anti-alpha-smooth muscle actin antibody and anti-pancytokeratin AE1/AE3 antibody. In pathologic findings, more fibrin deposits in intaalveolar lesions were observed in M. pneumonia than in BOOP. In intaalveolar lesions of M. pneumonia, a larger amount of nuclear debris, more neutrophils, and more erythrocytes were noted. Myofibroblasts were observed in the organization of BOOP, while in the intaalveolar lesions of M. pneumonia, myofibroblasts were not observed. These results suggest that M. pneumonia with intraalveolar exudates responds well to corticosteroid and its intraalveolar lesions apparently differed from those in BOOP.</p>
キーワード exudate fibrin Mycoplasma pneumonia organizing pneumonia steroid therapy
Amo Type Article
発行日 2002-04
出版物タイトル Acta Medica Okayama
56巻
2号
出版者 Okayama University Medical School
開始ページ 111
終了ページ 116
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 12002617
Web of Science KeyUT 000175176900008