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ID 13697
Eprint ID
13697
フルテキストURL
Thumnail 108_97.pdf 482 KB
タイトル(別表記)
Effect of granulocyte colony-stimulating factor (G-CSF) on allogeneic immune responses
著者
上山 聰 岡山大学医学部第一外科学教室
抄録
The administration of recombinant human granulocyte colony-stimulating factor (rhG-CSF) increased weight and cellularity of the spleen, leukocyte and granulocyte count of the peripheral blood in a dose- and duration-dependent fashion in mice. When spleen cells as well as serum from mice treated with intraperitoneal injection of 200μg/㎏ of rhG-CSF daily for 7 days were added to an allogeneic mixed lymphocyte reaction (MLR) culture, MLR was significantly suppressed nonspecifically and in a dose-dependent fashion. MLR was also suppressed by adding supernatant of spleen cells using transwells, indicating that suppression was mediated by soluble factor (s) secreted from the spleen cells. The producer cells of the inhibiting factor were found in more mature granulocytes with a high density in the spleen. These results suggested that the proliferated granulocytes induced by G-CSF produced and released factor (s) that suppress allogeneic immune responses.
キーワード
顆粒球コロニー刺激因子(granulocyte colony-stimulating factor ; G-CSF)
同種免疫応答
免疫抑制
リンパ球混合反応
備考
原著
発行日
1996-06-29
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
108巻
3-6号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
97
終了ページ
105
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/108/3-6/108_3-6_97/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma