フルテキストURL J_Org_Chem_80_6_3111.pdf
著者 Takamura, Hiroyoshi| Wada, Hiroko| Ogino, Mao| Kikuchi, Takahiro| Kadota, Isao| Uemura, Daisuke|
抄録 Four possible diastereomers of the C1-C13 fragment of symbiodinolide, which were proposed by the stereostructural analysis of the degraded product, were synthesized in a stereodivergent and stereoselective manner. The key transformations were aldol reaction of methyl acetoacetate with the aldehyde, diastereoselective reduction of the resulting β-hydroxy ketone, and the stereoinversion at the C6 position. Comparison of the (1)H NMR data between the four synthetic products and the degraded product revealed the relative stereostructure of the C1-C13 fragment of symbiodinolide.
備考 This is an Accepted Manuscript of an article published by American Chemical Society This research was supported by a Grant-in Aid for Scientific Research (No. 24710250) from the Japan Society for the Promotion of Science (JSPS).
発行日 2015-02-27
出版物タイトル The Journal of organic chemistry
80巻
6号
出版者 American Chemical Society
開始ページ 3111
終了ページ 3123
ISSN 00223263
NCID AA00704100
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 25723589
DOI 10.1021/acs.joc.5b00027
Web of Sience KeyUT 000351558400017
関連URL isVersionOf https://doi.org/10.1021/acs.joc.5b00027