JaLCDOI 10.18926/AMO/32299
フルテキストURL fulltext.pdf
著者 Okada, Shigeru| Taketa, Kazuhisa| Ishikawa, Takatoshi| Koji, Takehiko| Swe, Than| Win, Ne| Win, Khin Maung| Mra, Rai| Myint, Thein Thein|
抄録 <p>We conducted Myanmar-Japan cooperation studies on hepatitis B and hepatitis C virus markers in patients with thalassemias and those with liver diseases. Among the 102 patients with liver diseases, 92% had a history of hepatitis B virus infection (antibody to hepatitis B core antigen positive), 35% were hepatitis B surface antigen positive, 39% were positive for anti-HCV. Among 28 patients with hepatocellular carcinoma, 46% had hepatitis B surface antigen, 21.4% had antibody to hepatitis C virus, and 7% were positive for both hepatitis B surface antigen and anti hepatitis C virus. The history of HCV infection among blood recipients at the Haematology Department of the Yangon General Hospital and at the Yangon Children's Hospital was found to be 55.5% and 46.7%, respectively, which is comparable to the history of hepatitis B infection (66.7% and 46.7%, respectively). This preliminary survey also encountered 2 cases positive for anti-HCV among 34 voluntary blood donors. This survey is the first one to report that hepatitis C is at the epidemic stage in Myanmar. As there is no effective treatment for hepatitis C in this country, a screening program for blood used in transfusion should be started immediately.</p>
キーワード hepatitis C Myanmar (Burma) thalassemia hepatitis B
Amo Type Article
発行日 2000-06
出版物タイトル Acta Medica Okayama
54巻
3号
出版者 Okayama University Medical School
開始ページ 137
終了ページ 138
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 10925739
Web of Sience KeyUT 000087965700007
JaLCDOI 10.18926/AMO/31689
フルテキストURL fulltext.pdf
著者 Taketa, Kazuhisa| Okada, Shigeru| Win, Ne| Hlaing, Naomi Khaing Than| Win, Khin Maung|
抄録 <p>Levels of alpha-fetoprotein (AFP), its glycoforms AFP-L3 and AFP-P4, and proteins induced by vitamin K absence or antagonist-II (PIVKA-II) were determined in sera obtained from patients in Yangon General Hospital (20 with hepatocellular carcinoma (HCC), 29 with chronic liver diseases, including 3 with chronic hepatitis and 26 with cirrhosis of the liver, and 9 with other hepatobiliary diseases). Forty-five percent of the patients with HCC had serum AFP levels above 10,000 ng/ml, indicating that nearly half of the HCC patients were at an advanced stage of the disease. Thus, the AFP sensitivity was as high as 70% with 100% specificity for a cutoff level of 200 ng/ml. The sensitivity of AFP-L3 was 75% and a specificity 90% for a cutoff level of 15%. AFP-P4 showed a higher sensitivity of 80% and a similar specificity of 86% for a cutoff level of 12%. Combined evaluation of AFP-L3 and/or AFP-P4 increased the sensitivity to 90% with the same specificity of 86%, indicating that AFP-L3 and AFP-P4 are useful as adjuncts for diagnosis of HCC in the present population. PIVKA-II had a high sensitivity of 90%, although the specificity was lower than 45%, probably due to the low cutoff level, as some cholestatic patients were included in the control group.</p>
キーワード apoptosis spontaneously hypertensive rat osteonecrosis of the femoral head
Amo Type Article
発行日 2002-12
出版物タイトル Acta Medica Okayama
56巻
6号
出版者 Okayama University Medical School
開始ページ 317
終了ページ 320
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 12685861
Web of Sience KeyUT 000179959000007